抗体

兔多抗人类ITGA4/VLA-4/CD49d

MBS240166

0.05毫克

495美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠, 狗

免疫组化, 免疫组化-石蜡切片

抗体

兔多抗人类ITGA4/VLA-4/CD49d

ITGA4/VLA-4/CD49d

Anti-ITGA4 / VLA-4 / CD49d Antibody (C-Terminus) IHC-plus; ITGA4; 269C wild type; CD49D; IA4; Integrin alpha-4; Integrin alpha 4; Integrin alpha-4 subunit; Integrin alpha-IV; VLA-4; VLA-4 subunit alpha; CD49d antigen; Human ITGA4; VLA-4; CD49d

integrin alpha-4; Integrin alpha-4; integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 subunit; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d

ITGA4

VLA-4;CD49d

ITGA4;ITGA4;IA4;CD49D;CD49D

ITA4_HUMAN

多克隆

兔

Bat, Gibbon, Dog, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat. Predicted Reactivity: Bovine, Horse (at least 90% immunogen sequence identity)

1032

Human ITGA4 / Integrin Alpha 4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% 叠氮化钠

1毫克/毫升

Long term: -70 degree C; Short term: +4 degree C

免疫组化(免疫组化-石蜡)

IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic 18 amino acid peptide from C-terminus of human ITGA4 / Integrin Alpha 4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Hamster, Panda, Rabbit, Pig (100%).

Immunogen Type: Synthetic peptide. Immunogen: ITGA4 / VLA-4 / CD49d antibody was raised against synthetic 18 amino acid peptide from C-terminus of human ITGA4 / Integrin Alpha 4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Hamster, Panda, Rabbit, Pig (100%); Bovine, Elephant, Horse, Opossum, Platypus (94%). Antigen Modification: C-Terminus

Family: Integrin

ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function.

67191027

NP_000876.3

NM_000885.4

P13612

21,536 Da

Adaptive Immune System Pathway (366160); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 2q31.3. Cellular Component: focal adhesion; cell surface; membrane; plasma membrane; intercellular junction; external side of plasma membrane. Molecular Function: protein binding; metal ion binding; fibronectin binding; cell adhesion molecule binding. Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; heart development; cell-matrix adhesion; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; leukocyte tethering or rolling; blood coagulation; leukocyte migration

0.05毫克

495美元