抗体

兔多抗人类PTGS2/COX2/COX-2

MBS240526

0.05毫升

495美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

兔多抗人类PTGS2/COX2/COX-2

PTGS2/COX2/COX-2

Anti-PTGS2 / COX2 / COX-2 Antibody (C-Terminus) IHC-plus; PTGS2; COX-2; Cyclooxygenase-2; COX2; Cyclooxygenase 2b; HCox-2; GRIPGHS; PGH synthase 2; PGHS-2; PHS II; PHS-2; Prostaglandin H2 synthase 2; PGG/HS; Prostaglandin G/H synthase 2; Human PTGS2; COX2; COX-2

prostaglandin G/H synthase 2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase 2; PHS II; PGH synthase 2; cyclooxygenase 2b; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2

PTGS2

COX2;COX-2

PTGS2; PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; COX2; COX-2; PGH synthase 2; PGHS-2

PGH2_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

604

GST fusion protein, the epitope of which maps to the carboxy-terminus of human Cox-2.

Sterile filtered

0.01% 叠氮化钠

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

ELISA (1:10000 - 1:50000), IHC-P (1:500), WB (1:5000 - 1:10000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Fusion protein from human PTGS2 / COX-2.

Immunogen: PTGS2 / COX2 / COX-2 antibody was raised against fusion protein from human PTGS2 / COX-2. Antigen Modification: C-Terminus

Prostaglandin-endoperoxide synthase (fatty acid cyclooxygenase; PGH synthase; Cox-2) is a key enzyme in prostaglandin biosynthesis. The first rate-limiting step in the conversion of arachidonic acid to prostaglandins is catalyzed by Cox-1 and Cox-2. The cyclooxygenase activity of Cox-2 is inhibited by nonsteroidal antiinflammatory drugs such as aspirin and endomethacin.

4506265

NP_000954.1

NM_000963.3

P35354

68,996 Da

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); C-MYB Transcription Factor Network Pathway (138073); C20 Prostanoid Biosynthesis Pathway (545299); C20 Prostanoid Biosynthesis Pathway (908107); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237)

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1. Chromosomal Location of Human Ortholog: 1q25.2-q25.3. Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; caveola; nucleus. Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; protein homodimerization activity; enzyme binding; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding. Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; response to lithium ion; positive regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; decidualization; prostaglandin biosynthetic process; sensory perception of pain; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; bone mineralization; response to estradiol stimulus; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; nicotinamide metabolic process; negative regulation of smooth muscle contraction; regulation of blood pressure; arachidonic acid metabolic process; angiogenesis; positive regulation of smooth muscle contraction; inflammatory response; water-soluble vitamin metabolic process; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; vitamin metabolic process; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; hair cycle; prostaglandin metabolic process; ovulation; response to manganese ion; NAD metabolic process; regulation of inflammatory response; positive regulation of fever; positive regulation of vasoconstriction; brown fat cell differentiation; response to oxidative stress; cell motility; embryo implantation

0.05毫升

495美元