产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊多克隆抗人类CAV1/小窝蛋白1
目录 :
MBS240768
规格 :
0.05毫克
价格 :
495美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类, 黑猩猩
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS240768
产品类型 :
抗体
产品全称 :
山羊多克隆抗人类CAV1/小窝蛋白1
产品简称 :
CAV1/小窝蛋白1
产品名称同义词 :
Anti-CAV1 / Caveolin 1 Antibody (Internal) IHC-plus; CAV1; Caveolin-1; CGL3; CAV; MSTP085; VIP21; BSCL3; Human CAV1; Caveolin 1
其他名称 :
caveolin-1 isoform alpha; Caveolin-1; caveolin-1; cell growth-inhibiting protein 32; caveolin 1, caveolae protein, 22kDa
产品基因名称 :
CAV1
其他基因名称 :
CAV1;CAV1;CGL3;PPH3;BSCL3;LCCNS;VIP21;MSTP085;CAV
UniProt数据库进入名 :
CAV1_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Gibbon, Chimpanzee, Gorilla, Human, Monkey. Predicted Reactivity: Orangutan, Guinea pig (at least 90% immunogen sequence identity)
序列长度 :
178
特异性 :
Human CAV1 / Caveolin. No cross-reactivity expected to Caveolin 2 and Caveolin 3
纯度 :
Immunoaffinity Purified
形式 :
三羟甲基氨基甲烷缓冲盐液, pH值7.3, 0.5% BSA, 0.02% 叠氮化钠
浓度 :
0.5毫克/毫升
储存稳定性 :
Store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
ELISA (1:32000), IHC-P (2.5 ug/ml), WB (0.3 - 1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
其它信息1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-DELSEKQVYDAH from an internal region of human CAV1 / Caveolin (NP_001744.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (92%).
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: CAV1 / Caveolin 1 antibody was raised against synthetic peptide C-DELSEKQVYDAH from an internal region of human CAV1 / Caveolin (NP_001744.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (92%); Mouse, Rat, Dog, Bat, Hamster, Rabbit, Horse (83%). Antigen Modification: Internal
产品描述 :
Caveolin 1 (CAV1) is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 functions as a membrane adaptor to link integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 may also be a tumor suppressor gene and a negative regulator of the Ras-p42/44 MAP kinase cascade.
NCBI GI登录号 :
15451856
NCBI登录号 :
NP_001744.2
NCBI基因登录号 :
NM_001753.4
UniProt数据库登录号 :
Q03135
NCBI分子量 :
17,023 Da
NCBI信号通路 :
ALK1 Signaling Events Pathway (137968); Androgen Receptor Signaling Pathway (198806); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Basigin Interactions Pathway (106065); Canonical Wnt Signaling Pathway (138032); Cell Surface Interactions At The Vascular Wall Pathway (106062); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); EGFR1 Signaling Pathway (198782)
NCBI总结 :
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
UniProt数据库总结 :
Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation. Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q31.1. Cellular Component: focal adhesion; protein complex; endoplasmic reticulum; integral to plasma membrane; basolateral plasma membrane; lipid particle; cell cortex; caveola; cilium; acrosomal membrane; lipid raft; Golgi membrane; early endosome membrane; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; cytoplasmic vesicle; intracellular; endosome. Molecular Function: identical protein binding; protein binding; enzyme binding; protease activator activity; cholesterol binding; patched binding; protein complex scaffold; nitric-oxide synthase binding; structural molecule activity; protein kinase binding; receptor binding. Biological Process: mammary gland involution; viral reproduction; negative regulation of epithelial cell differentiation; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; negative regulation of BMP signaling pathway; calcium ion homeostasis; protein localization; sequestering of lipid; regulation of the force of heart contraction by chemical signal; regulation of fatty acid metabolic process; negative regulation of protein binding; inactivation of MAPK activity; maintenance of cellular protein localization; regulation of smooth muscle contraction; skeletal muscle development; cytosolic calcium ion homeostasis; negative regulation of nitric-oxide synthase activity; cellular response to starvation; membrane depolarization; cholesterol homeostasis; response to estrogen stimulus; T cell costimulation; negative regulation of endothelial cell proliferation; negative regulation of protein ubiquitination; regulation of nitric-oxide synthase activity; response to progesterone stimulus; response to calcium ion; negative regulation of JAK-STAT cascade; leukocyte migration; lactation; vesicle organization and biogenesis; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of pinocytosis; nitric oxide metabolic process; mammary gland development; calcium ion transport; negative regulation of cytokine and chemokine mediated signaling pathway; angiogenesis; vasculogenesis; protein homooligomerization; vasoconstriction; cholesterol transport; negative regulation of MAPKKK cascade; negative regulation of nitric oxide biosynthetic process; MAPKKK cascade; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; regulation of peptidase activity; cellular calcium ion homeostasis; triacylglycerol metabolic process; regulation of blood coagulation; response to hypoxia; positive regulation of vasoconstriction; vascular endothelial growth factor receptor signaling pathway; blood coagulation. Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。