抗体

兔多抗人类MMP2

MBS241057

0.05毫克

495美元

多克隆

兔

nonconjugated

酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

兔多抗人类MMP2

MMP2

Anti-MMP2 Antibody (aa87-102) IHC-plus; MMP2; 72 kd type iv collagenase; 72 kDa gelatinase; 72 kd gelatinase; 72 kDa type IV collagenase; CLG4A; CLG4; GelA; Gelatinase A; Matrix metalloproteinase-2; MMP-2; MONA; Neutrophil gelatinase; TBE-1; Tbe-1 metalloprotease; Collagenase type IV-A; Human MMP2

72 kDa type IV collagenase isoform 1 preproprotein; 72 kDa type IV collagenase; 72 kDa type IV collagenase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1PEX

MMP2

MMP2;MMP2;CLG4;MONA;CLG4A;基质金属蛋白酶-2;TBE-1;基质金属蛋白酶-II;CLG4A;基质金属蛋白酶-2

MMP2_HUMAN

多克隆

兔

人类

660

Amino acids 87 to 102 of human MMP2

蛋白质G纯化

PBS, 0.1% 叠氮化钠

1毫克/毫升

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

免疫组化(免疫组化-石蜡), 酶联免疫吸附测定(EIA)

ELISA (1:000 - 1:1000), IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide from human MMP2.

Immunogen Type: Synthetic peptide. Immunogen: MMP2 antibody was raised against synthetic peptide from human MMP2. Antigen Modification: aa87-102

Family: Protease. Subfamily: Metallopeptidase M10A

MMP2 is a Metallopeptidase M10A type protease.

11342666

NP_004521.1

NM_004530.5

P08253

68,831 Da

AGE/RAGE Pathway (698754); ATF-2 Transcription Factor Network Pathway (138006); Activation Of Matrix Metalloproteinases Pathway (576264); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Developmental Biology Pathway (477129)

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family. Protein type: Protease; Secreted, signal peptide; Apoptosis; Cell development/differentiation; EC 3.4.24.24; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16q12.2. Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere; mitochondrion; extracellular region; plasma membrane; nucleus. Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; serine-type endopeptidase activity. Biological Process: axon guidance; intramembranous ossification; extracellular matrix organization and biogenesis; proteolysis; blood vessel maturation; extracellular matrix disassembly; collagen catabolic process; cellular protein metabolic process; positive regulation of innate immune response; ephrin receptor signaling pathway; response to hypoxia; angiogenesis; embryo implantation. Disease: Multicentric Osteolysis, Nodulosis, And Arthropathy

0.05毫克

495美元