产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔多抗人类MMP7
目录 :
MBS241179
规格 :
0.05毫克
价格 :
495美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀
更多信息或购买 :
产品信息
目录号 :
MBS241179
产品类型 :
抗体
产品全称 :
兔多抗人类MMP7
产品简称 :
MMP7
产品名称同义词 :
Anti-MMP7 Antibody (C-Terminus) IHC-plus; MMP7; Matrilysin; Matrin; MMP-7; MPSL1; PUMP-1; Pump-1 protease; MPMM; Uterine matrilysin; Punctuated metalloproteinase 1; Matrix metalloproteinase-7; PUMP1; Uterine metalloproteinase; Human MMP7
其他名称 :
matrilysin preproprotein; Matrilysin; matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); matrix metallopeptidase 7 (matrilysin, uterine); Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase
产品基因名称 :
MMP7
其他基因名称 :
MMP7;MMP7;基质金属蛋白酶-7;MPSL1;PUMP-1;MPSL1;PUMP1;基质金属蛋白酶-7
UniProt数据库进入名 :
MMP7_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
267
特异性 :
肽来自C末端人的MMP7
纯度 :
Immunoaffinity Purified
形式 :
PBS, pH值7.4, 0.1% BSA, 0.05% 叠氮化钠
浓度 :
0.2毫克/毫升
储存稳定性 :
Store at 2-8 degree C for up to 1 year. Avoid repeated freeze-thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)
应用笔记 :
IHC-P (10 ug/ml), IP (2 - 5 ng/10E6 cells), WB (0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS241179 was determined to be 10 ug/ml.
其它信息1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human MMP7.
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: MMP7 antibody was raised against synthetic peptide from human MMP7. Antigen Modification: C-Terminus
产品种类 :
Family: Protease. Subfamily: Metallopeptidase M10A
产品描述 :
MMP7 is a Metallopeptidase M10A type protease. MMP-7 (Matrilysin) is constitutively produced by exocrine epithelial cells through out the body. It is capable of degrading casein, fibronectin, gelatins of types 1, III, IV, and V, in addition to activating procollagenase. It has been shown to play a key role in invasion by carcinomas.
NCBI GI登录号 :
4505219
NCBI登录号 :
NP_002414.1
NCBI基因登录号 :
NM_002423.3
UniProt数据库登录号 :
P09237
NCBI分子量 :
29,677 Da
NCBI信号通路 :
AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Alpha6-Beta4 Integrin Signaling Pathway (198807); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900); Syndecan-1-mediated Signaling Events Pathway (138046)
NCBI总结 :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.23. Chromosomal Location of Human Ortholog: 11q22.2. Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity. Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; defense response to Gram-positive bacterium; extracellular matrix organization and biogenesis; antibacterial peptide biosynthetic process; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。