产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Rabbit Polyclonal (IgG) to Human CCR1
目录 :
MBS241826
规格 :
0.05毫克
价格 :
495美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS241826
产品类型 :
抗体
产品全称 :
Rabbit Polyclonal (IgG) to Human CCR1
产品简称 :
CCR1
产品名称同义词 :
Anti-CCR1 Antibody IHC-plus; CCR1; C-C chemokine receptor type 1; CD191; CD191 antigen; CKR-1; CKR1; CMKBR1; CC-CKR-1; CMKR1; HM145; MIP-1 alpha; RANTES-R; RANTES receptor; SCYAR1; MIP-1 alpha receptor; C-C CKR-1; CCR-1; LD78 receptor; MIP-1alpha-R; MIP1aR; Human CCR1
其他名称 :
C-C chemokine receptor type 1; C-C chemokine receptor type 1; C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor; chemokine (C-C motif) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD_antigen: CD191
产品基因名称 :
CCR1
其他基因名称 :
CCR1;CCR1;CKR1;CD191;CKR-1;HM145;CMKBR1;MIP1aR;SCYAR1;CMKBR1;CMKR1;SCYAR1;C-C CKR-1;CC-CKR-1;CCR-1;CCR1;MIP-1alpha-R
UniProt数据库进入名 :
CCR1_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠
序列长度 :
355
特异性 :
A synthetic peptide of human CCR1 protein. It will cross react with mouse CCR1.
纯度 :
蛋白质G纯化
形式 :
PBS, 0.05% BSA, 0.02% 叠氮化钠
浓度 :
0.5毫克/毫升
储存稳定性 :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flo, IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: A synthetic peptide of human CCR1 protein. It will cross react with mouse CCR1.
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: CCR1 antibody was raised against a synthetic peptide of human CCR1 protein. It will cross react with mouse CCR1.
产品种类 :
Family: GPCR. Subfamily: Chemokine
产品描述 :
CCR1, a Chemokine Receptor, affects stem cell proliferation and mediates systemic inflammatory responses. This receptor is stimulated by the beta chemokines RANTES, MCP-1, and MIP-1 alpha. Disruption of CCR1 enhances protection from pulmonary inflammation and reduces the development of respiratory distress syndrome in rat.
NCBI GI登录号 :
4502631
NCBI登录号 :
NP_001286.1
NCBI基因登录号 :
NM_001295.2
UniProt数据库登录号 :
P32246
NCBI分子量 :
41,173 Da
NCBI信号通路 :
Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)
NCBI总结 :
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; phosphoinositide phospholipase C activity. Biological Process: exocytosis; positive regulation of osteoclast differentiation; metabolic process; cytokine and chemokine mediated signaling pathway; chemotaxis; cellular calcium ion homeostasis; negative regulation of bone mineralization; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; calcium ion transport; response to wounding; dendritic cell chemotaxis; immune response; cell adhesion; inflammatory response; positive regulation of calcium ion transport
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。