产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔多抗小鼠IL7R/CD127
目录 :
MBS242247
规格 :
0.05毫克
价格 :
495美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS242247
产品类型 :
抗体
产品全称 :
兔多抗小鼠IL7R/CD127
产品简称 :
IL7R/CD127
产品名称同义词 :
Anti-IL7R / CD127 Antibody (phospho-Tyr449) IHC-plus; IL7R; CD127; CD127 antigen; IL-7RA; IL-7 receptor subunit alpha; IL7RA; ILRA; Interleukin 7 receptor; CDW127; IL-7R subunit alpha; IL-7R-alpha; Mouse IL7R; CD127
其他名称 :
interleukin-7 receptor subunit alpha; Interleukin-7 receptor subunit alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; interleukin 7 receptor; CDw127; CD_antigen: CD127
产品基因名称 :
IL7R
产品基因名称同义词 :
CD127
其他基因名称 :
IL7R;IL7R;ILRA;CD127;IL7RA;CDW127;IL-7R;IL-7受体亚单位甲;IL-7R亚单位甲;IL-7R;IL-7RA
UniProt数据库进入名 :
IL7RA_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
459
特异性 :
A BLAST analysis was used to suggest cross-reactivity with IL-7R from human, mouse and rat sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-7R from other sources has not been determined.
纯度 :
Immunoaffinity Purified
形式 :
0.02 M钾磷酸盐, 0.15 M氯化钠, pH值7.2, 0.01% 叠氮化钠
浓度 :
1毫克/毫升
储存稳定性 :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
ELISA (1:100000), IHC-P (5 ug/ml), WB (1:1000 - 1:10000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Mouse. Immunogen Description: Synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: IL7R / CD127 antibody was raised against synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein. Antigen Modification: pTyr449
产品种类 :
Family: Interleukin
产品描述 :
Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation.
NCBI GI登录号 :
28610151
NCBI登录号 :
NP_002176.2
NCBI基因登录号 :
NM_002185.3
UniProt数据库登录号 :
P16871
NCBI分子量 :
28,724 Da
NCBI信号通路 :
Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); FoxO Signaling Pathway (921162); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-7 Signaling Pathway (198857); Immune System Pathway (106386); Interleukin-7 Signaling Pathway (530762); Jak-STAT Signaling Pathway (83077)
NCBI总结 :
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]
UniProt数据库总结 :
IL7R: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- positive/NK-cell-positive (T(-)B(+)NK(+) SCID). A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Genetic variations in IL7R are a cause of susceptibility to multiple sclerosis type 3 (MS3). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major C allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either C allele (Thr-244) or T allele (Ile-244) shows that the C allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated C risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Belongs to the type I cytokine receptor family. Type 4 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: integral to membrane; plasma membrane; extracellular region; external side of plasma membrane. Molecular Function: protein binding; interleukin-7 receptor activity; antigen binding. Biological Process: B cell proliferation; positive regulation of T cell differentiation in the thymus; cell surface receptor linked signal transduction; regulation of DNA recombination; negative regulation of T cell mediated cytotoxicity; cell morphogenesis; homeostasis of number of cells; immune response; immunoglobulin production; cell growth; signal transduction; lymph node development; regulation of cell size; T cell differentiation. Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。