抗体

兔多抗人类HMOX1/HO-1

MBS242394

0.05毫克

495美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠, 狗

免疫印迹, 免疫组化, 免疫沉淀

抗体

兔多抗人类HMOX1/HO-1

HMOX1/HO-1

Anti-HMOX1 / HO-1 Antibody IHC-plus; HMOX1; BK286B10; HO-1; HSP32; Heat shock protein; 32-kD; Heme oxygenase (decycling) 1; Heme oxygenase 1; HO1; Human HMOX1; HO-1

heme oxygenase 1; Heme oxygenase 1; heme oxygenase 1; heat shock protein, 32-kD; heme oxygenase (decycling) 1

HMOX1

HO-1

HMOX1;HMOX1;HO-1;HSP32;HMOX1D;bK286B10;HO;HO1;HO-1

HMOX1_HUMAN

多克隆

兔

Dog, Hamster, Human, Monkey, Mouse, Rabbit, Rat

288

蛋白质A纯化

PBS, 0.09% 叠氮化物, 50% 甘油

1毫克/毫升

Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.

免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)

IHC-P (10 ug/ml), IP (1:100), WB (1:1000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide derived from sequence near the amino-terminus of human HO-1 (Hsp32).

Immunogen Type: Synthetic peptide. Immunogen: HMOX1 / HO-1 antibody was raised against synthetic peptide derived from sequence near the amino-terminus of human HO-1 (Hsp32).

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

4504437

NP_002124.1

NM_002133.2

P09601

32,819 Da

HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); Heme Degradation Pathway (160971); Iron Uptake And Transport Pathway (187191); Keap1-Nrf2 Pathway (198777); Metabolism Pathway (477135); Metabolism Of Porphyrins Pathway (106325); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); Mineral Absorption Pathway (212237)

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

HMOX1: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. Expressed at higher levels in renal cancer tissue than in normal tissue. Belongs to the heme oxygenase family. Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; nucleolus; caveola; nucleus; cytosol. Molecular Function: signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; metal ion binding; phospholipase D activity; heme binding; heme oxygenase (decyclizing) activity. Biological Process: cell death; response to nicotine; cellular iron ion homeostasis; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; negative regulation of mast cell degranulation; excretion; positive regulation of vasodilation; erythrocyte homeostasis; regulation of transcription factor activity; heme catabolic process; small GTPase mediated signal transduction; regulation of blood pressure; porphyrin metabolic process; negative regulation of mast cell cytokine production; angiogenesis; negative regulation of neuron apoptosis; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; healing during inflammatory response; transmembrane transport; protein homooligomerization; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; heme oxidation; cellular response to nutrient; regulation of angiogenesis; negative regulation of leukocyte migration; negative regulation of DNA binding; iron ion homeostasis; positive regulation of angiogenesis; positive regulation of chemokine biosynthetic process; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; response to estrogen stimulus; endothelial cell proliferation; response to oxidative stress; smooth muscle hyperplasia. Disease: Heme Oxygenase 1 Deficiency; Pulmonary Disease, Chronic Obstructive

0.05毫克

495美元