产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔多抗人类MMP14
目录 :
MBS242536
规格 :
0.25毫升
价格 :
495美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录号 :
MBS242536
产品类型 :
抗体
产品全称 :
兔多抗人类MMP14
产品简称 :
MMP14
产品名称同义词 :
Anti-MMP14 Antibody (aa160-173) IHC-plus; MMP14; Membrane type-1 MMP; MT1-MMP; MT1MMP; MT-MMP; MT-MMP 1; Matrix metalloproteinase-14; MMP-14; MMP-X1; MTMMP1; Human MMP14
其他名称 :
matrix metalloproteinase-14 preproprotein; Matrix metalloproteinase-14; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; matrix metallopeptidase 14 (membrane-inserted); MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP
产品基因名称 :
MMP14
其他基因名称 :
MMP14;MMP14;基质金属蛋白酶-14;基质金属蛋白酶-X1;MT-基质金属蛋白酶;MT1MMP;MTMMP1;WNCHRS;MT1-基质金属蛋白酶;MT-基质金属蛋白酶1;基质金属蛋白酶-14;MT-基质金属蛋白酶1;MTMMP1;MT1-基质金属蛋白酶;MT1MMP
UniProt数据库进入名 :
MMP14_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类
序列长度 :
582
纯度 :
Immunoaffinity Purified
形式 :
10 mM PBS, pH值7.4, BSA, 叠氮化钠
浓度 :
0.2毫克/毫升
储存稳定性 :
Store at 2 degree C to 8 degree C degrees. Do not freeze.
检测过的应用 :
免疫组化(免疫组化-石蜡)
应用笔记 :
IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: A synthetic peptide derived from aa 160-173 of human MMP-14 protein.
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: MMP14 antibody was raised against a synthetic peptide derived from aa 160-173 of human MMP-14 protein. Antigen Modification: aa160-173
产品种类 :
Family: Protease. Subfamily: Metallopeptidase M10A
产品描述 :
MMP14 is a Metallopeptidase M10A type protease.
NCBI GI登录号 :
4826834
NCBI登录号 :
NP_004986.1
NCBI基因登录号 :
NM_004995.3
UniProt数据库登录号 :
P50281
NCBI分子量 :
65,894 Da
NCBI信号通路 :
AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502); HIF-2-alpha Transcription Factor Network Pathway (137956); Matrix Metalloproteinases Pathway (198900); Senescence And Autophagy Pathway (198780)
NCBI总结 :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
MMP14: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Up-regulated by NANOS1. Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. Belongs to the peptidase M10A family. Protein type: Protease; Membrane protein, integral; EC 3.4.24.80; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; focal adhesion; Golgi lumen; integral to plasma membrane; cytoplasm; melanosome; plasma membrane. Molecular Function: integrin binding; protein binding; protease activator activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; transcription factor activity. Biological Process: extracellular matrix organization and biogenesis; negative regulation of focal adhesion formation; male gonad development; tissue remodeling; embryonic cranial skeleton morphogenesis; proteolysis; positive regulation of cell growth; collagen catabolic process; extracellular matrix disassembly; branching morphogenesis of a tube; regulation of transcription, DNA-dependent; ovarian follicle development; response to mechanical stimulus; response to estrogen stimulus; endothelial cell proliferation; response to hypoxia; zymogen activation; response to oxidative stress; angiogenesis; astrocyte cell migration; endochondral ossification; positive regulation of cell migration; lung development. Disease: Winchester Syndrome
尺寸1 :
0.25毫升
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。