抗体

Chicken Polyclonal (IgY) to Mouse TUBB3 / Tubulin Beta 3

MBS244264

0.075毫克

495美元

多克隆

鸡

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

Chicken Polyclonal (IgY) to Mouse TUBB3 / Tubulin Beta 3

Ⅲ型β微管蛋白/微管蛋白乙3

Anti-TUBB3 / Tubulin Beta 3 Antibody IHC-plus; TUBB3; CDCBM; Beta III Tubulin; Class III beta-tubulin; TUBB4; Tubulin; beta 3; Tubulin beta-III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin; beta 3 class III; CFEOM3A; Mouse TUBB3; Tubulin Beta 3

tubulin beta-3 chain isoform 1; Tubulin beta-3 chain; tubulin beta-3 chain; tubulin beta-III; tubulin beta-4 chain; class III beta-tubulin; tubulin, beta 3 class III; Tubulin beta-4 chain; Tubulin beta-III

Ⅲ型β微管蛋白

Ⅲ型β微管蛋白;Ⅲ型β微管蛋白;CDCBM;FEOM3;TUBB4;CDCBM1;CFEOM3;乙4;CFEOM3A;TUBB4

TBB3_HUMAN

多克隆

IgY

鸡

Mouse. Predicted Reactivity: Human, Rat (at least 90% immunogen sequence identity)

450

Recognizes beta-Tubulin 3. Species cross-reactivity: mouse. Species sequence homology: rat, human.

Immunoaffinity Purified

10mM PBS, pH值7.2, 0.02% 叠氮化钠

0.3毫克/毫升

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months.

免疫组化(免疫组化-石蜡), 免疫细胞化学(免疫细胞化学), 免疫印迹(免疫印迹)

ICC (1:1000 - 1:2000), IHC-P (5 ug/ml), WB (1:2000 - 1:5000). Usage: Suitable for use in Immunohistochemistry, Immunocytochemistry and Western Blot. Immunohistochemistry: 1:1000-1:2000. Immunocytochemistry: 1:1000-1:2000. Western Blot: 1:2000-1:5000.

Target Species: Mouse. Immunogen Description: Three synthetic peptides corresponding to different regions of the beta-Tubulin 3 (KLH). Species sequence homology: human (NP_AAL28094, NCBI), rat (AAM28438, NCBI) 100%.

Immunogen Type: Synthetic peptide - KLH conjugated. Immunogen: TUBB3 / Tubulin Beta 3 antibody was raised against three synthetic peptides corresponding to different regions of the beta-Tubulin 3 (KLH). Species sequence homology: human (NP_AAL28094, NCBI), rat (AAM28438, NCBI) 100%.

Family: Tubulin

50592996

NP_006077.2

NM_006086.3

Q13509

42,433 Da

Chaperonin-mediated Protein Folding Pathway (106242); Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway (106243); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway (106245); Gap Junction Pathway (83072); Gap Junction Pathway (483); Metabolism Of Proteins Pathway (106230); Orphan Transporters Pathway (1127546); Parkin-Ubiquitin Proteasomal System Pathway (700638); Pathogenic Escherichia Coli Infection Pathway (83103)

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]

TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 16q24.3. Cellular Component: microtubule; cell soma; axon; cytoplasm; dendrite; nucleus. Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; peptide binding. Biological Process: protein polymerization; de novo posttranslational protein folding; mitosis; axon guidance; cellular protein metabolic process; protein folding; transmembrane transport; microtubule-based process. Disease: Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement; Cortical Dysplasia, Complex, With Other Brain Malformations 1

0.075毫克

495美元