MyBioSource

抗体

Mouse Monoclonal (IgG1) to Human ER Alpha / Estrogen Receptor

MBS245027

0.05毫升

495美元

单克隆

小鼠

nonconjugated

免疫印迹, 免疫组化

MBS245027

抗体

Mouse Monoclonal (IgG1) to Human ER Alpha / Estrogen Receptor

ER甲/雌激素受体

Anti-ER Alpha / Estrogen Receptor Antibody (aa410-592) IHC-plus; Era; ERalpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha; ER Alpha; Human ER Alpha; Estrogen Receptor

estrogen receptor isoform 1; Estrogen receptor; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1; estrogen receptor 1; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

ESR1

ESR1; ESR1; ER; ESR; Era; ESRA; ESTRR; NR3A1; ESR; NR3A1; ER

ESR1_HUMAN

单克隆

IgG1

小鼠

人类

595

Ni-NTA purified recombinant human ER-alpha (410-592aa) expressed in E Coli strain BL21 (DE3)

蛋白质A纯化

PBS, pH值7.4, 0.03% 叠氮化钠

1毫克/毫升

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹)

IHC-P (1:800), WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Recombinant human ESR1 / Estrogen receptor.

Immunogen Type: Recombinant protein. Immunogen: ER Alpha / Estrogen Receptor antibody was raised against recombinant human ESR1 / Estrogen receptor. Antigen Modification: aa410-592

Family: NHR. Subfamily: NR3 Steroid receptor

Estrogen receptor alpha, a NR3 Steroid Receptor, activates transcription of a wide variety of genes in response to estrogen, particularly in reproductive tissues. Recent studies have shown that ER alpha also can function in a ligand-independent and DNA binding- independent manner, as well as through cell-surface signaling. ER alpha functions have also been demonstrated via the selective ER modulator (SERM) ligands and their various ER signaling pathways.

62821794

NP_000116.2

NM_000125.3

P03372

35,547 Da

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

0.05毫升

495美元