抗体

Mouse Monoclonal [clone MEM-48] (IgG1) to Human ITGB2 / MAC-1 / CD18

MBS245100

0.05毫克

530美元

单克隆

小鼠

未共轭

[最小必需培养基-48]

免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪, 流式细胞仪

抗体

Mouse Monoclonal [clone MEM-48] (IgG1) to Human ITGB2 / MAC-1 / CD18

[ITGB2/MAC-1/CD18]

[Anti-ITGB2 / MAC-1 / CD18 Antibody (clone MEM-48) IHC-plus; ITGB2; CD18 antigen; CD18; Integrin beta chain; beta 2; LCAMB; MAC-1; MFI7; MF17; Integrin beta-2; LAD; LFA-1; Human ITGB2; MAC-1; CD18]

[integrin beta-2; Integrin beta-2; integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18]

[ITGB2]

[MAC-1;CD18]

[ITGB2;ITGB2;LAD;CD18;MF17;MFI7;LCAMB;LFA-1;MAC-1;CD18;MFI7]

ITB2_HUMAN

单克隆

IgG1

[最小必需培养基-48]

小鼠

人类

769

Leukocytes of a patient suffering from a LGL-type leukemia

蛋白质A纯化

PBS, 15 mM sodium azide, approx., pH 7.4.

1毫克/毫升

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Functional Assay

Flo (2 ug/ml), Func, IHC-Fr, IHC-P (10 ug/ml), IP (2 ug/ml), WB (2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

免疫组化(免疫组化)

Target Species: Human. Immunogen: ITCB2/CD18 antibody was raised against Human. Immunogen Species: ITCB2/CD18 antibody was raised against cells.

Family: Integrin

Recognizes an epitope involving residues 534-546 incysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on al leukocytes. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

89191865

NP_000202.2

NM_000211.3

P05107

Adaptive Immune System Pathway (366160); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); CXCR3-mediated Signaling Events Pathway (138011); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); HIF-1-alpha Transcription Factor Network Pathway (138045)

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1). Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: cell surface; membrane; plasma membrane; integrin complex; vesicle; receptor complex; lipid raft. Molecular Function: protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; ICAM-3 receptor activity; cell adhesion molecule binding; glycoprotein binding; protein kinase binding. Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cell-cell signaling; cellular extravasation; inflammatory response; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; endothelial cell migration; innate immune response; blood coagulation; leukocyte migration. Disease: Leukocyte Adhesion Deficiency, Type I

0.05毫克

530美元