产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone PC10] (IgG2a) to Human PCNA / Cyclin
目录 :
MBS245134
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
PC10
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪, 流式细胞仪
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS245134
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone PC10] (IgG2a) to Human PCNA / Cyclin
产品简称 :
增殖细胞核抗原/细胞周期蛋白
产品名称同义词 :
Anti-PCNA / Cyclin Antibody (clone PC10) IHC-plus; Cyclin; Human PCNA; Cyclin
其他名称 :
proliferating cell nuclear antigen; Proliferating cell nuclear antigen; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein; proliferating cell nuclear antigen; Cyclin
产品基因名称 :
增殖细胞核抗原
其他基因名称 :
增殖细胞核抗原;增殖细胞核抗原;ATLD2;增殖细胞核抗原
UniProt数据库进入名 :
PCNA_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a
克隆 :
PC10
宿主 :
小鼠
反应物种 :
人类, 小鼠
序列长度 :
261
特异性 :
重组大鼠增殖细胞核抗原
纯度 :
亲和纯化
形式 :
磷酸盐缓冲液溶液, pH值7.2, 0.09% 叠氮化钠
浓度 :
0.5毫克/毫升
储存稳定性 :
Store at 4 degree C. Do not freeze.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flo, IHC-P (10 ug/ml), IP, WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: Recombinant human PCNA.
其他信息2 :
Immunogen Type: Recombinant protein. Immunogen: PCNA / Cyclin antibody was raised against recombinant human PCNA.
NCBI GI登录号 :
4505641
NCBI登录号 :
NP_002583.1
NCBI基因登录号 :
NM_002592.2
UniProt数据库登录号 :
P12004
NCBI分子量 :
28,769 Da
NCBI信号通路 :
BARD1 Signaling Events Pathway (137959); BRCA1-associated Genome Surveillance Complex (BASC) Pathway (413428); BRCA1-associated Genome Surveillance Complex (BASC) Pathway (890555); Base Excision Repair Pathway (105838); Base Excision Repair Pathway (83043); Base Excision Repair Pathway (451); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054)
NCBI总结 :
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
PCNA: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3 - 5 exonuclease and 3 -phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone. Interacts with KCTD10 and PPP1R15A. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH. Interacts with NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with p21Cip1/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with DDX11. Interacts with EGFR; positively regulates PCNA. Interacts with C12orf48/PARI. Interacts with SMARCAD1. Belongs to the PCNA family. Protein type: DNA replication; Cell cycle regulation. Chromosomal Location of Human Ortholog: 20pter-p12. Cellular Component: nucleoplasm; centrosome; PCNA complex; cytoplasm; nuclear replication fork; DNA replication factor C complex; nucleus. Molecular Function: identical protein binding; protein binding; DNA polymerase processivity factor activity; purine-specific mismatch base pair DNA N-glycosylase activity; MutLalpha complex binding; receptor tyrosine kinase binding; dinucleotide insertion or deletion binding. Biological Process: mismatch repair; positive regulation of deoxyribonuclease activity; heart development; DNA strand elongation during DNA replication; DNA repair; response to lipid; leading strand elongation; telomere maintenance via semi-conservative replication; G1/S-specific transcription in mitotic cell cycle; cell proliferation; bypass DNA synthesis; response to cadmium ion; epithelial cell differentiation; base-excision repair; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; telomere maintenance; G1/S transition of mitotic cell cycle; regulation of DNA replication. Disease: Ataxia-telangiectasia-like Disorder 2
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。