产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4
目录 :
MBS245186
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
76B357.1
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS245186
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4
产品简称 :
Toll样受体4
产品名称同义词 :
Anti-TLR4 Antibody (aa100-200, clone 76B357.1) IHC-plus; TLR4; CD284; CD284 antigen; Homolog of Drosophila toll; TLR-4; TOLL; ARMD10; Toll-like receptor 4; HToll; Human TLR4
其他名称 :
toll-like receptor 4 isoform C; Toll-like receptor 4; toll-like receptor 4; hToll; homolog of Drosophila toll; toll-like receptor 4; hToll; CD_antigen: CD284
产品基因名称 :
Toll样受体4
其他基因名称 :
Toll样受体4;Toll样受体4;TOLL;CD284;TLR-4;ARMD10
UniProt数据库进入名 :
TLR4_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2b, k
克隆 :
76B357.1
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
799
特异性 :
A portion of amino acids 100-200 of human TLR4.
纯度 :
蛋白质G纯化
形式 :
PBS, 0.05% BSA, 0.05% 叠氮化钠
浓度 :
0.5毫克/毫升
储存稳定性 :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flo, IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human TLR4.
其他信息2 :
Immunogen Type: Synthetic peptide. Immunogen: TLR4 antibody was raised against synthetic peptide from human TLR4. Antigen Modification: aa100-200
产品种类 :
Family: Toll-like Receptor
产品描述 :
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide.
NCBI GI登录号 :
4507533
NCBI登录号 :
NP_003257.1
NCBI基因登录号 :
NM_003266.3
UniProt数据库登录号 :
O00206
NCBI分子量 :
73,301 Da
NCBI信号通路 :
Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957!!HIF-1 Signaling Pathway 695200!!Hepatitis B Pathway 694606!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090
NCBI总结 :
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
规格 :
0.05毫克
价格 :
495美元
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。