产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone 31A1067] (IgG) to Human CASP3 / Caspase 3
目录 :
MBS245207
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
31A1067
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS245207
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone 31A1067] (IgG) to Human CASP3 / Caspase 3
产品简称 :
CASP3/胱氨酸-天冬氨酸蛋白酶3
产品名称同义词 :
Anti-CASP3 / Caspase 3 Antibody (clone 31A1067) IHC-plus; CASP3; Apopain; CASP-3; Caspase-3; CPP32B; CPP32; Cysteine protease CPP32; SCA-1; SREBP cleavage activity 1; Yama; Procaspase3; Caspase 3; CPP-32; PARP cleavage protease; Protein Yama; Human CASP3; Caspase 3
其他名称 :
caspase-3 preproprotein; Caspase-3; caspase-3; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; caspase 3, apoptosis-related cysteine peptidase; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
产品基因名称 :
CASP3
其他基因名称 :
CASP3;CASP3;CPP32;SCA-1;CPP32B;CPP32;CASP-3;CPP-32;SCA-1
UniProt数据库进入名 :
CASP3_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG
克隆 :
31A1067
宿主 :
小鼠
反应物种 :
人类, 小鼠
序列长度 :
277
特异性 :
Full-length recombinant human caspase-3 protein was used as immunogen. The antibody recognizes an epitope in the large domain subunit of Caspase-3. As such it will recognize pro Caspase-3 and the large subunit cleavage fragment.
纯度 :
蛋白质G纯化
形式 :
PBS, 0.05% BSA, 0.05% 叠氮化钠
浓度 :
0.5毫克/毫升
储存稳定性 :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹)
应用笔记 :
IHC-P (5 ug/ml), WB (2 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: Recombinant human CASP3 / Caspase 3.
其他信息2 :
Immunogen Type: Recombinant protein. Immunogen: CASP3 / Caspase 3 antibody was raised against recombinant human CASP3 / Caspase 3.
产品种类 :
Family: Protease. Subfamily: Cysteine C14
产品描述 :
Caspase 3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase 3 proteolytically cleaves and activates other proteins. Caspase 3 has been associated with apoptosis.
NCBI GI登录号 :
14790119
NCBI登录号 :
NP_004337.2
NCBI基因登录号 :
NM_004346.3
UniProt数据库登录号 :
P42574
NCBI分子量 :
31,608 Da
NCBI信号通路 :
AGE/RAGE Pathway 698754!!Activation Of DNA Fragmentation Factor Pathway 105683!!Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway 105672!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975
NCBI总结 :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
规格 :
0.05毫克
价格 :
495美元
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。