产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone E11] (IgG1) to Human CR1 / CD35
目录 :
MBS245363
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
E11
反应物种 :
人类, 猕猴
应用 :
免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS245363
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone E11] (IgG1) to Human CR1 / CD35
产品简称 :
CR1/CD35
产品名称同义词 :
Anti-CR1 / CD35 Antibody (clone E11, Azide-free) IHC-plus; CR1; C3b/C4b receptor; C3-binding protein; CD35; C3BR; Knops blood group antigen; C4BR; CD35 antigen; Complement receptor type 1; KN; Human CR1; CD35
其他名称 :
complement receptor type 1 isoform S; Complement receptor type 1; complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component (3b/4b) receptor 1 (Knops blood group); C3b/C4b receptor; CD_antigen: CD35
产品基因名称 :
CR1
产品基因名称同义词 :
CD35
其他基因名称 :
CR1;CR1;KN;C3BR;C4BR;CD35;C3BR
UniProt数据库进入名 :
CR1_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
E11
宿主 :
小鼠
反应物种 :
Cynomolgus monkey, Rhesus monkey, Baboon, Human
序列长度 :
2489
特异性 :
Is a single chain cell surface glycoprotein which exists in four allotypic forms (A, B, C, D) of 190kD, 220kD, 160kD and 250kD respectively. The molecule is expressed by granulocytes, monocytes, B cells and some T cells. Functionally CD35 acts as a receptor for the C3b component of complement. Clone E11 has been reported to be suitable for use in Western Blot.
纯度 :
蛋白质A纯化
形式 :
PBS, pH值7.4。 来源在TCS
浓度 :
1毫克/毫升
储存稳定性 :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
检测过的应用 :
免疫组化(免疫组化-石蜡;免疫组化-冷冻), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flo (1:50 - 1:100), IHC-Fr, IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
其它信息1 :
Target Species: Human. Immunogen Description: Human acute monocytic leukaemia cells.
其他信息2 :
Immunogen Type: Cells. Immunogen: CR1 / CD35 antibody was raised against human acute monocytic leukaemia cells. Antibody Modification: Azide-free
产品种类 :
Family: Protease. Subfamily: Serine S1
NCBI GI登录号 :
86793109
NCBI登录号 :
NP_000642.3
NCBI基因登录号 :
NM_000651.4
UniProt数据库登录号 :
P17927
NCBI分子量 :
223,663 Da
NCBI信号通路 :
Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200); Legionellosis Pathway (469186)
NCBI总结 :
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding. Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway. Disease: Knops Blood Group System; Malaria, Susceptibility To
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。