产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal (IgG2a,k) to Human IL2RA / CD25
目录 :
MBS245666
规格 :
0.5毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS245666
产品类型 :
抗体
产品全称 :
Mouse Monoclonal (IgG2a,k) to Human IL2RA / CD25
产品简称 :
IL2RA/CD25
产品名称同义词 :
Anti-IL2RA / CD25 Antibody IHC-plus; IL2RA; CD25 antigen; CD25; IDDM10; IL-2 receptor subunit alpha; IL2R; Interleukin 2 receptor; alpha; IL-2-RA; IL2-RA; TCGFR; IL-2R subunit alpha; p55; TAC antigen; Human IL2RA; CD25
其他名称 :
白细胞介素2受体亚单位甲;白细胞介素2受体亚单位甲;白细胞介素2受体亚单位甲;TAC抗原;IL-2R亚单位甲;IL-2受体亚单位甲;白细胞介素2受体, 甲;TAC抗原;p55;CD_antigen:CD25
产品基因名称 :
IL2RA
产品基因名称同义词 :
CD25
其他基因名称 :
IL2RA;IL2RA;p55;CD25;IL2R;TCGFR;IDDM10;IL-2受体亚单位甲;IL-2;IL-2R亚单位甲;白细胞介素-RA
UniProt数据库进入名 :
IL2RA_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a, k
宿主 :
小鼠
反应物种 :
人类
序列长度 :
272
特异性 :
人类IL-2Ralpha
纯度 :
蛋白质G纯化
形式 :
冻干来自PBS
浓度 :
1 mg/ml (After resuspension)
储存稳定性 :
Store Lyophilized at room temperature up to 1 month; Reconstituted for up to two weeks at 2-8 degree C. Aliquot and freeze at -20 degree C for long term storage. Avoid freeze/thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡;免疫组化-冷冻), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
ELISA, IHC-Fr (5 ug/ml), IHC-P (10 ug/ml), WB (0.2 - 0.4 ug/ml)
其它信息1 :
Target Species: Human. Target: IL2RA/CD25. Resuspension Liquid Description: Reconstitute in sterile water. Immunogen: IL2RA/CD25 antibody was raised against insect cell derived recombinant Human sIL-2Ralpha. Immunogen Species: IL2RA/CD25 antibody was raised against Human.
其他信息2 :
Antigen Type: Cell extract
产品种类 :
Family: Interleukin
产品描述 :
Immunohistochemistry: MBS245666 in an IHC-plus antibody, validated by our pathologists for use in IHC against formalin-fixed, paraffin-embedded human tissues (IHC validation procedure). A concentration of 10 ug/ml is recommended. ELISA: In a sandwich ELISA (assuming 100 ul/well), a concentration of 4-8 ug/ml of this antibody will detect at least 100 pg/ml of recombinant Human sIL-2Ralpha when used in conjunction with compatible secondary reagents. Western Blot: To detect Human sIL-2Ralpha by Western Blot analysis this antibody can be used at a concentration of 0.20-0.40 ug/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant Human sIL-2Ralpha is 2-4 ng/lane, under non-reducing conditions.
NCBI GI登录号 :
4557667
NCBI登录号 :
NP_000408.1
NCBI基因登录号 :
NM_000417.2
UniProt数据库登录号 :
P01589
NCBI信号通路 :
Arf6 Trafficking Events Pathway (137954); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Beta:gamma Signalling Through PI3Kgamma Pathway (119540)
NCBI总结 :
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
UniProt数据库总结 :
IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 10p15-p14. Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding. Biological Process: regulation of T cell homeostatic proliferation; Notch signaling pathway; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; cell surface receptor linked signal transduction; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis. Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10
尺寸1 :
0.5毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。