产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone 3B3] (IgG1) to Human ACTA1 / ASMA
目录 :
MBS245785
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3B3
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS245785
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone 3B3] (IgG1) to Human ACTA1 / ASMA
产品简称 :
ACTA1/ASMA
产品名称同义词 :
Anti-ACTA1 / ASMA Antibody (clone 3B3) IHC-plus; ACTA1; ACTA; Actin; alpha skeletal muscle; Alpha-actin-1; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; ASMA; NEM3; Human ACTA1; ASMA
其他名称 :
肌动蛋白, 甲骨骼肌;肌动蛋白, 甲骨骼肌;肌动蛋白, 甲骨骼肌;杆状体肌病类型3;肌动蛋白, 甲1, 骨骼肌;阿尔法肌动蛋白
产品基因名称 :
ACTA1
产品基因名称同义词 :
ASMA
其他基因名称 :
ACTA1;ACTA1;ACTA;ASMA;CFTD;MPFD;NEM1;NEM2;NEM3;CFTD1;CFTDM;ACTA
UniProt数据库进入名 :
ACTS_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
3B3
宿主 :
小鼠
反应物种 :
山羊, 人类, 猪, 兔, 大鼠
序列长度 :
377
特异性 :
Highly specific for alpha- skeletal actin, and does not cross react with other actin isoforms. The epitope recognized by 3B3 is highly conserved. Therefore the antibody cross-reacts with many other species.
纯度 :
纯化
形式 :
PBS含0.09% 叠氮化钠
浓度 :
1毫克/毫升
储存稳定性 :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡;免疫组化-冷冻), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
ELISA, IHC-Fr (1:100 - 1:1000), IHC-P (10 ug/ml), WB (1:1000 - 1:5000)
其它信息1 :
Target Species: Human. Immunogen Description: Peptide comprising the N-terminal nonapeptide of alpha-skeletal actin with an acetylated N-terminus (Ac-DEDETTALVC-COOH) coupled to keyhole limpet hemocyanin through the cysteine residue
产品描述 :
Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus. The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity.
NCBI GI登录号 :
4501881
NCBI登录号 :
NP_001091.1
NCBI基因登录号 :
NM_001100.3
UniProt数据库登录号 :
P68133
NCBI分子量 :
42,051 Da
NCBI信号通路 :
Caspase Cascade In Apoptosis Pathway (137974); Hypothetical Network For Drug Addiction Pathway (198776); Myometrial Relaxation And Contraction Pathways (198759); RhoA Signaling Pathway (169356); Signaling Events Mediated By Focal Adhesion Kinase Pathway (169348); Striated Muscle Contraction Pathway (198903)
NCBI总结 :
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family. Protein type: Cell development/differentiation; Cytoskeletal; Contractile; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q42.13. Cellular Component: extracellular space; sarcomere; stress fiber; actin filament; cytosol; striated muscle thin filament; actin cytoskeleton. Molecular Function: protein binding; myosin binding; structural constituent of cytoskeleton; ADP binding; ATP binding. Biological Process: skeletal muscle fiber adaptation; muscle contraction; muscle thin filament assembly; response to steroid hormone stimulus; response to mechanical stimulus; response to extracellular stimulus; response to lithium ion; skeletal muscle fiber development; cell growth; muscle filament sliding. Disease: Nemaline Myopathy 3; Myopathy, Congenital, With Fiber-type Disproportion
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。