抗体

Mouse Monoclonal (IgG1,k) to Human CCL20 / MIP-3-Alpha

MBS245814

0.5毫克

495美元

单克隆

小鼠

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

Mouse Monoclonal (IgG1,k) to Human CCL20 / MIP-3-Alpha

CCL20/MIP-3-Alpha

Anti-CCL20 / MIP-3-Alpha Antibody IHC-plus; CCL20; Beta chemokine exodus-1; Beta-chemokine exodus-1; CKb4; Exodus-1; MIP-3a; MIP-3-alpha; LARC; ST38; SCYA20; C-C motif chemokine 20; CC chemokine LARC; Mip-3alpha; MIP3A; Small-inducible cytokine A20; Human CCL20; MIP-3-Alpha

C-C motif chemokine 20 isoform 1; C-C motif chemokine 20; C-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (C-C motif) ligand 20; Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20Cleaved into the following 3 chains:CCL20(1-67); CCL20(1-64); CCL20(2-70)

CCL20

CCL20; CCL20; CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha; LARC; MIP3A; SCYA20; MIP-3-alpha

CCL20_HUMAN

单克隆

IgG1, k

小鼠

人类

96

人类MIP-3alpha

蛋白质A纯化

冻干来自PBS。 来源在TCS

1毫克/毫升

Store Lyophilized at room temperature up to 1 month; Reconstituted for up to two weeks at 2-8 degree C. Aliquot and freeze at -20 degree C for long term storage. Avoid freeze/thaw cycles.

免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

ELISA (2 - 4 ug/ml), IHC-P (10 ug/ml), WB (0.2 - 0.4 ug/ml). Usage: Immunohistochemistry: in an IHC-plus antibody, validated by our pathologists for use in IHC against formalin-fixed, paraffin-embedded human tissues (IHC validation procedure). A concentration of 10 ug/ml is recommended. ELISA: In a sandwich.

Target Species: Human. Resuspension Liquid Description: 500 ul sterile water. Immunogen Description: E.coli derived recombinant Human MIP-3alpha.

Immunogen Type: Cell extract. Immunogen: CCL20 / MIP-3-Alpha antibody was raised against e.coli derived recombinant Human MIP-3alpha.

Family: Intercrine. Subfamily: Intercrine beta

Chemokines are a family of related proteins that regulate leukocyte migration (including into tissues) and activation in the face of inflammatory stimulus. CCL20/LARC/EXODUS/MIP-3 has been shown to be highly expressed in liver, and preferentially in lymphocytes and monocytes where its expression is upregulated by mediators of inflammation.

4759076

NP_004582.1

NM_004591.2

P78556

10,691 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); EBV LMP1 Signaling Pathway (198790); G Alpha (i) Signalling Events Pathway (119550)

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q36.3. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity. Biological Process: cell-cell signaling; wound healing; defense response to bacterium; immune response; inflammatory response; chemotaxis; signal transduction; positive regulation of interleukin-1 alpha biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process

0.5毫克

495美元