抗体

Mouse Monoclonal [clone 61D3] (IgG1,k) to Human CD14

MBS245943

0.1毫克

495美元

单克隆

小鼠

未共轭

61D3

免疫组化, 流式细胞仪, 流式细胞仪

抗体

Mouse Monoclonal [clone 61D3] (IgG1,k) to Human CD14

CD14

Anti-CD14 Antibody (clone 61D3) IHC-plus; CD14; CD14 molecule; CD14 antigen; Human CD14

monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; CD14 molecule; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14Cleaved into the following 2 chains:Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form

CD14

CD14;CD14

CD14_HUMAN

单克隆

IgG1, k

61D3

小鼠

人类

375

亲和纯化

PBS, pH值7.2, 150 mM氯化钠, 0.09% 叠氮化钠

0.5毫克/毫升

Store at 4 degree C, avoid repeated freeze thaw cycles.

免疫组化(免疫组化-石蜡), 流式细胞仪(FC/流式细胞仪)

Flo, IHC-P (20 ug/ml). Usage: The 61D3 antibody has been tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at less than or equal to 1 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final vol.

Target Species: Human. Immunogen Description: Human CD14

CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells.

4557417

NP_000582.1

NM_000591.3

P08571

40,076 Da

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200)

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; cell surface; extracellular region; plasma membrane; endosome membrane; lipid raft. Molecular Function: peptidoglycan receptor activity; protein binding; opsonin receptor activity; lipopolysaccharide binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; apoptosis; MyD88-independent toll-like receptor signaling pathway; positive regulation of endocytosis; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; phagocytosis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to magnesium ion; response to ethanol; cell surface receptor linked signal transduction; response to heat; toll-like receptor signaling pathway; innate immune response; response to electrical stimulus; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of cytokine secretion

0.1毫克

495美元