产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Monoclonal [clone 10E5] (IgG2b) to Rat IL6
目录 :
MBS245946
规格 :
0.05毫克
价格 :
495美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1.00E+06
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS245946
产品类型 :
抗体
产品全称 :
Mouse Monoclonal [clone 10E5] (IgG2b) to Rat IL6
产品简称 :
白细胞介素-6
产品名称同义词 :
Anti-IL6 Antibody (clone 10E5) IHC-plus; IL6; B-cell stimulatory factor 2; BSF-2; BSF2; CTL differentiation factor; Hybridoma growth factor; IFN-beta-2; Interleukin-6; Interferon beta-2; Interleukin BSF-2; IFNB2; B-cell differentiation factor; CDF; HSF; IL-6; Rat IL6
其他名称 :
interleukin-6; Interleukin-6; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; interleukin 6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
产品基因名称 :
白细胞介素-6
其他基因名称 :
白细胞介素-6;白细胞介素-6;HGF;HSF;BSF2;IL-6;IFNB2;IFNB2;IL-6;BSF-2;CDF;IFN乙
UniProt数据库进入名 :
IL6_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2b
克隆 :
1.00E+06
宿主 :
小鼠
反应物种 :
大鼠
序列长度 :
212
特异性 :
识别白细胞介素6(IL-6)
纯度 :
蛋白质G纯化
形式 :
PBS, pH 7.2. No stabilizers or preservatives added.
浓度 :
1毫克/毫升
储存稳定性 :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
检测过的应用 :
免疫组化(免疫组化-石蜡), 免疫印迹(免疫印迹), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flo, IHC-P (10 ug/ml), WB (0.1 - 1 ug/ml). Usage: Suitable for use in Flow Cytometry, Western Blot and Dot Blot. Flow Cytometry: 0.25 ug stains 1E6 rat peritoneal macrophages stimulated with LPS. Western Blot: 0.1-1 ug/ml. Dot Blot: 0.1-1 ug/ml.
其它信息1 :
Target Species: Rat. Immunogen Description: Purified recombinant rat IL-6.
其他信息2 :
Immunogen Type: Recombinant protein. Immunogen: IL6 antibody was raised against purified recombinant rat IL-6.
产品种类 :
Family: Hormone
产品描述 :
Interleukin-6 (IL6) is a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this IL6 is implicated in a wide variety of inflammation-associated disease states, including susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
NCBI GI登录号 :
10834984
NCBI登录号 :
NP_000591.1
NCBI基因登录号 :
NM_000600.3
UniProt数据库登录号 :
P05231
NCBI分子量 :
23,718 Da
NCBI信号通路 :
ARMS-mediated Activation Pathway (106466); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Adipogenesis Pathway (198832); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Axon Guidance Pathway (105688); Cellular Senescence Pathway (905991)
NCBI总结 :
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
UniProt数据库总结 :
IL6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7p21. Cellular Component: extracellular space; cytoplasm; extracellular region; interleukin-6 receptor complex; external side of plasma membrane. Molecular Function: protein binding; interleukin-6 receptor binding; growth factor activity; cytokine activity. Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; negative regulation of collagen biosynthetic process; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; response to glucocorticoid stimulus; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; glucose homeostasis; bone remodeling; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; response to caffeine; muscle maintenance; response to antibiotic; regulation of cell shape; monocyte chemotaxis; positive regulation of T-helper 2 cell differentiation; positive regulation of acute inflammatory response; negative regulation of gluconeogenesis; acute-phase response; positive regulation of T cell proliferation; response to electrical stimulus; cell growth; defense response to virus; neurite development; response to drug; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of interleukin-6 production; defense response to protozoan; negative regulation of fat cell differentiation; response to amino acid stimulus; positive regulation of chemokine production; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; response to heat; cell redox homeostasis; positive regulation of B cell activation; negative regulation of protein kinase activity; neutrophil apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of muscle development; positive regulation of translation; positive regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; neutrophil mediated immunity; regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of caspase activity; defense response to Gram-negative bacterium; response to insulin stimulus; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to peptidoglycan; positive regulation of cell proliferation; hepatic immune response; inflammatory response; aging; negative regulation of chemokine biosynthetic process; response to nutrient levels; cytokine and chemokine mediated signaling pathway; positive regulation of immunoglobulin secretion; regulation of angiogenesis; positive regulation of peptidyl-serine phosphorylation; endocrine pancreas development; humoral immune response; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; response to cold; positive regulation of neuron differentiation; positive regulation of DNA replication; positive regulation of transmission of nerve impulse. Disease: Rheumatoid Arthritis, Systemic Juvenile; Arteriovenous Malformations Of The Brain; Kaposi Sarcoma, Susceptibility To; Inflammatory Bowel Disease 1
尺寸1 :
0.05毫克
价格1 :
495美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。