抗体

Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha

MBS247657

0.125毫升

495美元

多克隆

兔

未共轭

P17-V

抗体

Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha

CD8A/CD8甲

Anti-CD8A / CD8 Alpha Antibody (C-Terminus, clone P17-V) IHC-plus; CD8A; CD8a molecule; CD8a antigen; OKT8 T-cell antigen; Leu2 T-lymphocyte antigen; T8 T-cell antigen; T cell co-receptor; p32; CD8; Leu2; T-cell antigen Leu2; CD8 Alpha; Human CD8A; CD8 Alpha

T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a

CD8A

CD8A;CD8A;CD8;MAL;p32;Leu2;MAL

CD8A_HUMAN

多克隆

P17-V

兔

人类

235

人类CD8

纯化

20 mM三羟甲基氨基甲烷氯化氢, pH值8.0, 20毫克/毫升BSA, 0.05% 叠氮化钠

2.5毫克/毫升

Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.

免疫组化(免疫组化-石蜡;免疫组化-冷冻)

IHC-Fr (1:100 - 1:200), IHC-P (1:25 - 1:100). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Peptide derived from C-terminal region of human CD8.

Immunogen: CD8A / CD8 Alpha antibody was raised against peptide derived from C-terminal region of human CD8. Antigen Modification: C-Terminus

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain.

22902134

NP_001759.3

NM_001768.6

P01732

30,214 Da

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386)

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p12. Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; MHC class I protein binding; coreceptor activity; protein kinase binding. Biological Process: antigen processing and presentation; regulation of immune response; T cell activation; T cell mediated immunity; cytotoxic T cell differentiation; positive regulation of calcium-mediated signaling; immune response; defense response to virus; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Cd8 Deficiency, Familial

0.125毫升

495美元