抗体

MMP1多克隆抗体

MBS2519111

0.02毫升

110美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

MMP1多克隆抗体

[MMP1]

[CLG;CLGN]

[MMP1 protein, partial; Interstitial collagenase; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1; matrix metallopeptidase 1 (interstitial collagenase); Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1]

[MMP1]

[MMP1;MMP1;CLG;CLGN;CLG;基质金属蛋白酶-1]

MMP1_HUMAN

多克隆

IgG

兔

人类, 小鼠

232

亲和纯化

PBS with 0.05% sodium azide, 50% glycerol, pH 7.3

2.2毫克/毫升

Store at -20 degree C. Avoid freeze / thaw cycles.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:200-1:1000。 IHC: 1:50-1:200

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫组化(免疫组化)

Cancer; Cell biology; Epigenetics

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

15341877

AAH13118.1

BC013875

54,007 Da

Activation Of Matrix Metalloproteinases Pathway (576264); Basigin Interactions Pathway (106065); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Cell Surface Interactions At The Vascular Wall Pathway (106062); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Endothelins Pathway (137958); Extracellular Matrix Organization Pathway (576262); Glucocorticoid Receptor Regulatory Network Pathway (138014)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat s mediated neurotoxicity. Belongs to the peptidase M10A family. Protein type: Secreted, signal peptide; EC 3.4.24.7; Motility/polarity/chemotaxis; Secreted; Protease. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: proteinaceous extracellular matrix; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding. Biological Process: collagen catabolic process; extracellular matrix disassembly; positive regulation of protein oligomerization; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; proteolysis; blood coagulation; leukocyte migration. Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive

0.02毫升

110美元

0.06毫升

150

0.12毫升

225

0.2毫升

360