产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
胰岛素样生长因子结合蛋白3抗体
目录 :
MBS2521889
规格 :
0.06毫升
价格 :
195美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2521889 图像 1
Immunofluorescent analysis of HeLa cells using IGFBP3 Polyclonal Antibody at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
图像 2 :
MyBioSource MBS2521889 图像 2
Immunohistochemical of paraffinembedded human breast cancer using IGFBP3 Polyclonal Antibody at dilution of 1:50 (under 10x lens)
产品信息
目录号 :
MBS2521889
产品类型 :
抗体
产品全称 :
胰岛素样生长因子结合蛋白3抗体
产品简称 :
[胰岛素样生长因子结合蛋白3]
产品名称同义词 :
[BP53, IBP3, IBP 3, IGF结合蛋白3, IGFBP 3, 胰岛素样生长因子结合蛋白3]
其他名称 :
[insulin-like growth factor-binding protein 3 isoform a; Insulin-like growth factor-binding protein 3; insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; insulin-like growth factor binding protein 3]
产品基因名称 :
[胰岛素样生长因子结合蛋白3]
其他基因名称 :
[胰岛素样生长因子结合蛋白3;胰岛素样生长因子结合蛋白3;IBP3;碱基对-53;IBP3;IBP-3;IGF结合蛋白3;IGFBP-3]
UniProt数据库进入名 :
IBP3_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠
序列长度 :
297
纯度 :
抗原亲和纯化
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)
应用笔记 :
WB: 1:200-1:1000。 IHC: 1:20-1:200。 IF : 1:10-1:100
image1头 :
十二烷基磺酸钠-PAGE
image2头 :
免疫荧光
image3头 :
Immunohistochemical
其他信息2 :
Immunogen: Fusion protein of IGFBP3. Buffer: PBS with 0.1% sodium azide, 50% glycerol, pH 7.3
产品描述 :
Background: Insulin-like growth factor binding protein-3 (IGFBP-3) contains a 27 amino acid putative signal sequence followed by a mature protein of 264 amino acids with 18 cysteine residues clustered near the N- and C-terminus. Accordingly, expression of the cloned IGFBP-3 cDNA in mammalian tissue culture cells results in secretion of the protein into the culture medium. IGFBP-3 shares high homology (33% amino acid identity) including conservation of all 18 cysteine residues with a smaller human IGF-binding protein (BP-28) identified in amniotic fluid.
NCBI GI登录号 :
62243248
NCBI登录号 :
NP_001013416.1
NCBI基因登录号 :
NM_001013398.1
NCBI分子量 :
32 kDa
NCBI信号通路 :
Direct P53 Effectors Pathway (137939); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Senescence And Autophagy Pathway (198780); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
NCBI总结 :
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; nucleus. Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; metal ion binding; fibronectin binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity. Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of catalytic activity; regulation of insulin-like growth factor receptor signaling pathway; apoptosis; negative regulation of smooth muscle cell proliferation; positive regulation of apoptosis; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of myoblast differentiation; negative regulation of signal transduction; osteoblast differentiation; negative regulation of cell proliferation; cellular protein metabolic process; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; regulation of cell growth
尺寸1 :
0.06毫升
价格1 :
195美元
尺寸2 :
0.12毫升
价格2 :
270
size3 :
0.2毫升
价格3 :
435
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。