产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
IL17A抗体
目录 :
MBS2523519
规格 :
0.06毫升
价格 :
195美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2523519 图像 1
U-937 cells were subjected to SDS PAGE followed by western blot with IL 17 A antibody at dilution of l:500
图像 2 :
MyBioSource MBS2523519 图像 2
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using IL 17 A Antibody at dilution of 1 :200 (under 40x lens).
产品信息
目录号 :
MBS2523519
产品类型 :
抗体
产品全称 :
IL17A抗体
产品简称 :
[IL17A]
产品名称同义词 :
[毒性T 淋巴细胞相关抗原8, CTLA8, 白细胞介素17, IL 17A, 白细胞介素-17, IL-17, IL17A, 白细胞介素17A]
其他名称 :
[白细胞介素17A;白细胞介素17A;白细胞介素17A;CTLA-8;细胞毒性T淋巴细胞 抗原8;细胞毒性T淋巴细胞 蛋白8;白细胞介素17(细胞毒性T淋巴细胞 丝氨酸酯酶8);白细胞介素17A;细胞毒性T淋巴细胞 抗原8;CTLA-8]
产品基因名称 :
[IL17A]
其他基因名称 :
[IL17A;IL17A;白细胞介素-17;CTLA8;IL-17;IL-17A;CTLA8;白细胞介素-17;IL-17;IL-17A;CTLA-8]
UniProt数据库进入名 :
IL17_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠
序列长度 :
155
纯度 :
抗原亲和纯化
储存稳定性 :
Store at -20 degree C. Avoid freeze / thaw cycles
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:200-1:2000。 IHC: 1:50-1:500
image1头 :
十二烷基磺酸钠-PAGE
image2头 :
免疫组化
其它信息1 :
Immunogen: Fusion protein of IL17. Calculated Molecular Weight: 155aa; 18kDa. Observed Molecular Weight: 32-35kDa
其他信息2 :
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
产品描述 :
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF -kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression oflL6 and cyclooxygenase-2 (pTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody got 32-35 kDa band in western blot, maybe due to homodimer formation and differential glycosylations.
NCBI GI登录号 :
2498481
NCBI登录号 :
Q16552
UniProt数据库登录号 :
BC067505
NCBI信号通路 :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL17 Signaling Pathway (920968); IL23-mediated Signaling Events Pathway (138000); IL27-mediated Signaling Events Pathway (137929); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269); TCR Signaling Pathway (198862)
NCBI总结 :
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 6p12. Cellular Component: extracellular space; external side of plasma membrane. Molecular Function: cytokine activity. Biological Process: cell death; cell-cell signaling; positive regulation of interleukin-23 production; apoptosis; positive regulation of osteoclast differentiation; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
尺寸1 :
0.06毫升
价格1 :
195美元
尺寸2 :
0.12毫升
价格2 :
270
size3 :
0.2毫升
价格3 :
435
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。