产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
NLRP3多克隆抗体
目录 :
MBS2523957
规格 :
0.02毫升
价格 :
110美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2523957 图像 1
Western Blot analysis of K562 and hela cell using NLRP3 Polyclonal Antibody at dilution of 1:88
产品信息
目录号 :
MBS2523957
产品类型 :
抗体
产品全称 :
NLRP3多克隆抗体
产品简称 :
[NLRP3]
产品名称同义词 :
[AII;AVP;FCU;MWS;FCAS;CIAS1;NALP3;C1orf7;CLR1.1;PYPAF1;AGTAVPRL]
其他名称 :
[NACHT, LRR and PYD domains-containing protein 3 isoform e; NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; PYRIN-containing APAF1-like protein 1; caterpiller protein 1.1; cold autoinflammatory syndrome 1 protein; cryopyrin; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; NLR family, pyrin domain containing 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1]
产品基因名称 :
[NLRP3]
其他基因名称 :
[NLRP3;NLRP3;AII;AVP;FCU;MWS;FCAS;CIAS1;FCAS1;NALP3;C1orf7;CLR1.1;PYPAF1;AGTAVPRL;C1orf7;CIAS1;NALP3;PYPAF1;CLR1.1]
UniProt数据库进入名 :
NALP3_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类
序列长度 :
1034
纯度 :
亲和纯化
浓度 :
0.1毫克/毫升
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
WB: 1:200-1:1000
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen: Recombinant protein of human NLRP3
其他信息2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
产品种类 :
Cancer; Cell biology
产品描述 :
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NCBI GI登录号 :
341865590
NCBI登录号 :
BC117211
NCBI基因登录号 :
NM_001243133.1
UniProt数据库登录号 :
Q96P20
NCBI分子量 :
118kDa
NCBI信号通路 :
Immune System Pathway (106386); Inflammasomes Pathway (366166); Influenza A Pathway (217173); Influenza A Pathway (217150); Innate Immune System Pathway (106387); NOD Pathway (198792); NOD-like Receptor Signaling Pathway (122191); NOD-like Receptor Signaling Pathway (122131); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (366164); Pertussis Pathway (218111)
NCBI总结 :
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
UniProt数据库总结 :
NLRP3: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1); also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS); also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs. Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA); also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Inhibitor. Chromosomal Location of Human Ortholog: 1q44. Cellular Component: cytoplasm; cytosol. Molecular Function: protein binding; peptidoglycan binding; ATP binding. Biological Process: caspase activation; apoptosis; negative regulation of acute inflammatory response; positive regulation of caspase activity; interleukin-1 beta production; defense response; negative regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of interleukin-1 beta secretion; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; interleukin-18 production; innate immune response; interleukin-1 secretion; detection of biotic stimulus; inflammatory response; defense response to virus. Disease: Cinca Syndrome; Familial Cold Autoinflammatory Syndrome 1; Muckle-wells Syndrome
尺寸1 :
0.02毫升
价格1 :
110美元
尺寸2 :
0.06毫升
价格2 :
150
size3 :
0.12毫升
价格3 :
225
size4 :
0.2毫升
price4 :
360
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。