产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
ERBB4多克隆抗体
目录 :
MBS2524475
规格 :
0.02毫升
价格 :
110美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2524475 图像 1
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using ERBB4 Polyclonal Antibody at dilution 1:40
图像 2 :
MyBioSource MBS2524475 图像 2
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ERBB4 Polyclonal Antibody at dilution 1:40
产品信息
目录号 :
MBS2524475
产品类型 :
抗体
产品全称 :
ERBB4多克隆抗体
产品简称 :
[ERBB4]
产品名称同义词 :
[HER4;ALS19;p180erbB4]
其他名称 :
[ERBB4 protein; Receptor tyrosine-protein kinase erbB-4; receptor tyrosine-protein kinase erbB-4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; erb-b2 receptor tyrosine kinase 4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4ERBB4 intracellular domain; 4ICD; E4ICDAlternative name(s):s80HER4]
产品基因名称 :
[ERBB4]
其他基因名称 :
[ERBB4;ERBB4;HER4;ALS19;p180erbB4;HER4;4ICD;E4ICD]
UniProt数据库进入名 :
ERBB4_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
1282
纯度 :
亲和纯化
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫组化(免疫组化)
应用笔记 :
IHC: 1:50-1:200
image1头 :
免疫组化(免疫组化)
image2头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Recombinant protein of human ERBB4
其他信息2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
产品种类 :
Cancer; Epigenetics
产品描述 :
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation.
NCBI GI登录号 :
219520060
NCBI登录号 :
BC112199
UniProt数据库登录号 :
Q15303
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downregulation Of ERBB4 Signaling Pathway (530745); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250)
NCBI总结 :
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported. Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; EGFR family. Chromosomal Location of Human Ortholog: 2q33.3-q34. Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; basolateral plasma membrane; plasma membrane; extracellular region; integral to membrane; cytosol; nucleus; receptor complex. Molecular Function: protein binding; protein homodimerization activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding. Biological Process: lactation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; protein amino acid autophosphorylation; embryonic pattern specification; signal transduction; olfactory bulb interneuron differentiation; regulation of cell migration; negative regulation of cell proliferation; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; fibroblast growth factor receptor signaling pathway; cell fate commitment; phosphoinositide-mediated signaling; transcription, DNA-dependent; positive regulation of phosphoinositide 3-kinase activity; cell proliferation; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response; positive regulation of protein amino acid phosphorylation; mitochondrial fragmentation during apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis. Disease: Amyotrophic Lateral Sclerosis 19
尺寸1 :
0.02毫升
价格1 :
110美元
尺寸2 :
0.06毫升
价格2 :
150
size3 :
0.12毫升
价格3 :
225
size4 :
0.2毫升
price4 :
360
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。