抗体

CTNND1抗体

MBS2524951

0.06毫升

150美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学

抗体

CTNND1抗体

[CTNND1]

[CAS登记号码;CTNND;KIAA0384;P120CAS;P120CTN;p120]

[catenin delta-1 isoform 1AC; Catenin delta-1; catenin delta-1; cadherin-associated Src substrate; p120 catenin; catenin (cadherin-associated protein), delta 1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)]

[CTNND1]

[CTNND1; CTNND1; CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN); KIAA0384; CAS; p120(ctn)]

CTND1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

939

亲和纯化

存放在-20°C。 避免反复冷冻/解冻

免疫印迹(免疫印迹), 免疫荧光(IF)

免疫印迹(免疫印迹)1:500-1:2000。 免疫荧光(IF)1:50-1:200

免疫印迹(免疫印迹)

免疫荧光(IF)

Immunogen: Recombinant protein of human CTNND1. Calculated MW: 65-72kDa/90-108kDa. Observed MW: 105kDa

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1730 / sc-13957

Catenin delta-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin delta-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin delta-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin delta-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to beta-catenin, catenin delta-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin delta-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin delta-1 may function as a tumor suppressor (4). Phosphorylation of Tyr904 on Catenin-delta-1 was identified at Cell Signaling Technology (CST) using PhosphoScan, a CST's LC-MS/MS platform for phosphorylation site discovery (5).

332688210

NP_001193814.1

NM_001206885.1

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (119533); Arf6 Trafficking Events Pathway (137954); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); E-cadherin Signaling In Keratinocytes Pathway (138002); E-cadherin Signaling In The Nascent Adherens Junction Pathway (138005); EGFR1 Signaling Pathway (198782)

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described. Protein type: Actin-binding; G protein regulator, misc.; Adaptor/scaffold; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 11q11. Cellular Component: growth cone; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intercellular junction; zonula adherens; midbody; cytosol; nucleus. Molecular Function: protein binding; cadherin binding; protein kinase binding; receptor binding. Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; brain development; cell adhesion; vascular endothelial growth factor receptor signaling pathway

0.06毫升

150美元

0.12毫升

225

0.2毫升

360