产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CRKL多克隆抗体
目录 :
MBS2525825
规格 :
0.02毫升
价格 :
110美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
Western Blot analysis of Lovo, Raji and A172 cell using CRKL Polyclonal Antibody at dilution of 1:600
图像 2 :
Immunohistochemistry of paraffin-embedded Human thyroid cancer using CRKL Polyclonal Antibody at dilution of 1:25
图像 3 :
Immunohistochemistry of paraffin-embedded Human gastric cancer using CRKL Polyclonal Antibody at dilution of 1:25
产品信息
目录号 :
MBS2525825
产品类型 :
抗体
产品全称 :
CRKL多克隆抗体
产品简称 :
[CRKL]
其他名称 :
[crk-like protein; Crk-like protein; crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like]
产品基因名称 :
[CRKL]
其他基因名称 :
[CRKL;CRKL]
UniProt数据库进入名 :
CRKL_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
303
纯度 :
抗原亲和纯化
浓度 :
2.3毫克/毫升
储存稳定性 :
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:500-1:2000。 IHC: 1:25-1:100
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Synthetic peptide of human CRKL. Calculated Molecular Weight: 34kDa
其他信息2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
产品描述 :
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
NCBI GI登录号 :
4885153
NCBI登录号 :
NP_005198.1
NCBI基因登录号 :
NM_005207.3
NCBI分子量 :
34kDa
NCBI信号通路 :
B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Cytokine Signaling In Immune System Pathway (366171); Downstream Signal Transduction Pathway (106385); EGFR1 Signaling Pathway (198782)
NCBI总结 :
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
UniProt数据库总结 :
CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: cytosol; endosome. Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity. Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; thymus development; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
尺寸1 :
0.02毫升
价格1 :
110美元
尺寸2 :
0.06毫升
价格2 :
150
size3 :
0.12毫升
价格3 :
225
size4 :
0.2毫升
price4 :
360
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。