产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
乙酰磷酸酶张力蛋白同源基因(K402)多克隆抗体
目录 :
MBS2537217
规格 :
0.02毫升
价格 :
110美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2537217 图像 1
Western Blot analysis of HepG2 cells with PTEN (Acetyl Lys402) Polyclonal Antibody.
产品信息
目录号 :
MBS2537217
产品类型 :
抗体
产品全称 :
乙酰磷酸酶张力蛋白同源基因(K402)多克隆抗体
产品简称 :
[磷酸酶张力蛋白同源基因]
产品名称同义词 :
[PTEN; MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog]
其他名称 :
[PTEN; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog]
产品基因名称 :
[磷酸酶张力蛋白同源基因]
其他基因名称 :
[磷酸酶张力蛋白同源基因;磷酸酶张力蛋白同源基因;BZS;DEC;CWS1;GLM2;MHAM;TEP1;MMAC1;PTEN1;10q23del;MMAC1;TEP1]
UniProt数据库进入名 :
PTEN_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
403
纯度 :
亲和纯化
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C. Avoid freeze / thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1:500-1:2000, ELISA: 1:5000-1:20000
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen: Synthesized peptide derived from the human PTEN around the acetylation site of K402. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
其他信息2 :
Calculated MW: 47 kDa. Observed MW: 47 kDa
产品种类 :
Cancer; Cell biology; Epigenetics
NCBI GI登录号 :
4240387
NCBI登录号 :
AAD13528.1
NCBI分子量 :
Calculated MW: 47. Observed MW: 47
NCBI信号通路 :
3-phosphoinositide Degradation Pathway (545349); 3-phosphoinositide Degradation Pathway (139488); Adaptive Immune System Pathway (1269171); Androgen Receptor Signaling Pathway (198806); BCR Signaling Pathway (138058); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Class I PI3K Signaling Events Pathway (138022); D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway (545328); D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway (138943)
NCBI总结 :
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
UniProt数据库总结 :
PTEN: a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Protein type: EC 3.1.3.48; Tumor suppressor; Phosphatase, lipid; EC 3.1.3.16; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; EC 3.1.3.67; Carbohydrate Metabolism - inositol phosphate. Chromosomal Location of Human Ortholog: 10q23.3. Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytosol; dendritic spine; extracellular region; internal side of plasma membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic membrane. Molecular Function: enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity. Biological Process: adult behavior; aging; anaphase-promoting complex activation during mitotic cell cycle; angiogenesis; apoptosis; brain morphogenesis; cardiac muscle development; cell migration; cell proliferation; central nervous system development; central nervous system neuron axonogenesis; dentate gyrus development; endothelial cell migration; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; forebrain morphogenesis; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; heart development; innate immune response; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; male mating behavior; maternal behavior; memory; multicellular organismal response to stress; myelin maintenance in the central nervous system; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of focal adhesion formation; negative regulation of myelination; negative regulation of organ growth; negative regulation of phagocytosis; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; nerve growth factor receptor signaling pathway; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phosphoinositide-mediated signaling; phospholipid metabolic process; platelet-derived growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of transcription factor activity; prepulse inhibition; protein amino acid dephosphorylation; protein kinase B signaling cascade; protein stabilization; regulation of axon regeneration; regulation of B cell apoptosis; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of myeloid cell apoptosis; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to arsenic; response to ATP; response to drug; response to estradiol stimulus; response to ethanol; response to glucose stimulus; response to nutrient; response to zinc ion; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; T cell receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin. Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
尺寸1 :
0.02毫升
价格1 :
110美元
尺寸2 :
0.06毫升
价格2 :
150
size3 :
0.12毫升
价格3 :
225
size4 :
0.2毫升
price4 :
360
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。