产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Di-Methyl-p53 (K370) Polyclonal Antibody
目录 :
MBS2539431
规格 :
0.02毫升
价格 :
110美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
Western Blot analysis of MCF7, K562 cells with p53 (Di-Methyl-Lys370) Polyclonal Antibody.
图像 2 :
Immunohistochemistry of paraffin-embedded Human breast tissue using p53 (Di-Methyl-Lys370) Polyclonal Antibody at dilution of 1:100.
图像 3 :
Immunofluorescence analysis of Human breast cancer tissue using p53 (Di-Methyl-Lys370) Polyclonal Antibody at dilution of 1:200.
产品信息
目录号 :
MBS2539431
产品类型 :
抗体
产品全称 :
Di-Methyl-p53 (K370) Polyclonal Antibody
产品简称 :
[Di-Methyl-p53]
产品名称同义词 :
[TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
纯度 :
亲和纯化
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
免疫印迹, 免疫组化-p, IF, 酶联免疫吸附测定
应用笔记 :
免疫印迹1:500-1:2000。 免疫组化1:100-300。 IF 1:50-1:200。 酶联免疫吸附测定1:10000-1:20000
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫荧光(IF)
其它信息1 :
Immunogen: Synthesized peptide derived from human p53 around the di-methylation site of K370. Calculated MW: 44kDa. Observed MW: 53kDa. Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
产品种类 :
Cancer; Cell biology
产品描述 :
Background: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclindependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
UniProt数据库登录号 :
P04637
UniProt数据库总结 :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
尺寸1 :
0.02毫升
价格1 :
110美元
尺寸2 :
0.06毫升
价格2 :
150
size3 :
0.12毫升
价格3 :
225
size4 :
0.2毫升
price4 :
360
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。