抗体

NOTCH2多克隆抗体

MBS2540022

0.06毫升

150美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 免疫组化

抗体

NOTCH2多克隆抗体

[NOTCH2]

[hN2;AGS2;HJCYS]

[neurogenic locus notch homolog protein 2 isoform 2; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; notch 2]

[NOTCH2]

[NOTCH2;NOTCH2;hN2;AGS2;HJCYS;N2ICD]

NOTC2_HUMAN

多克隆

IgG

兔

人类, 小鼠

1235

亲和纯化

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20 degree C. Avoid freeze/ thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:500 - 1:2000。 IHC: 1:100 - 1:200

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫组化(免疫组化)

Immunogen: Recombinant protein of human NOTCH2

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32344 / sc-32346 / sc-5545

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factorlike (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

317008611

NP_001186930.1

NM_001200001.1

Q04721

Calculated MW: 265kDa. Observed MW: 120kDa

Defective LFNG Causes SCDO3 Pathway (1383053); Delta-Notch Signaling Pathway (198879); Disease Pathway (1268854); Diseases Associated With O-glycosylation Of Proteins Pathway (1383049); Diseases Of Glycosylation Pathway (1269010); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); MicroRNAs In Cancer Pathway (852705)

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1p13-p11. Cellular Component: cell surface; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex. Molecular Function: protein binding. Biological Process: apoptosis; bone remodeling; cell cycle arrest; cell fate determination; cell growth; hemopoiesis; marginal zone B cell differentiation; negative regulation of apoptosis; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; positive regulation of Ras protein signal transduction; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter. Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome

0.06毫升

150美元

0.12毫升

225

0.2毫升

360