抗体

白细胞介素多克隆抗体

MBS2540143

0.02毫升

110美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

白细胞介素多克隆抗体

[白细胞介素]

[Aldesleukin; IL 2; IL2; interleukin 2; lymphokine; T cell growth factor; TCGF; POIL2; OTTHUMP00000164090]

[interleukin-2; Interleukin-2; interleukin-2; interleukin 2; T-cell growth factor; TCGF; INN: Aldesleukin]

[白细胞介素]

[白细胞介素;白细胞介素;IL-2;TCGF;淋巴因子;IL-2;TCGF]

IL2_HUMAN

多克隆

IgG

兔

大鼠, 小鼠

153

亲和纯化

Store at -20 degree C. Avoid freeze/ thaw cycles.

免疫组化(免疫组化)

Immunohistochemistry: 1:50-1:100

免疫组化(免疫组化)

免疫组化(免疫组化)

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen: Recombinant Mouse Interleukin-2 protein. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48544 / sc-34796 / sc-48545 / sc-7896

Cancer

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

28178861

NP_000577.2

NM_000586.3

P60568

ARMS-mediated Activation Pathway (1269471); AhR Pathway (755436); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Axon Guidance Pathway (1270303); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chagas Disease (American Trypanosomiasis) Pathway (147809)

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Cytokine; Secreted, signal peptide; Secreted; Oncoprotein. Chromosomal Location of Human Ortholog: 4q26-q27. Cellular Component: extracellular region; extracellular space. Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity. Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation

0.02毫升

110美元

0.06毫升

150

0.12毫升

225

0.2毫升

360