产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
v-erb-b2成红细胞白血病病毒致瘤基因2单克隆抗体
目录 :
MBS2540273
规格 :
0.06毫升
价格 :
220美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS2540273
产品类型 :
抗体
产品全称 :
v-erb-b2成红细胞白血病病毒致瘤基因2单克隆抗体
产品简称 :
[v-erb-b2成红细胞白血病病毒致瘤基因2]
产品名称同义词 :
[CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Protooncogene c ErbB 2, Proto oncogene Neu, TKR1]
其他名称 :
[receptor tyrosine-protein kinase erbB-2 isoform b; Receptor tyrosine-protein kinase erbB-2; receptor tyrosine-protein kinase erbB-2; erb-b2 receptor tyrosine kinase 2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340]
产品基因名称 :
[v-erb-b2成红细胞白血病病毒致瘤基因2]
其他基因名称 :
[ERBB2; ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; HER2; MLN19; NEU; NGL; MLN 19]
克隆性 :
单克隆
抗体亚型 :
IgG2b
宿主 :
小鼠
反应物种 :
人类
序列长度 :
1225
纯度 :
蛋白质A纯化
形式 :
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
免疫组化(免疫组化), 酶联免疫吸附测定(EIA)
应用笔记 :
Immunohystochemistry: 1:50-1:400
其它信息1 :
Immunogen: Fusion protein of HER2/ErbB2
产品种类 :
Cancer; Immunology; Signal transduction; Tags & Cell Markers
产品描述 :
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.
NCBI GI登录号 :
54792098
NCBI登录号 :
NP_001005862.1
NCBI基因登录号 :
NM_001005862.2
UniProt数据库登录号 :
P04626
NCBI分子量 :
1255aa, 138kDa
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Alpha6-Beta4 Integrin Signaling Pathway (198807); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535)
NCBI总结 :
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
尺寸1 :
0.06毫升
价格1 :
220美元
尺寸2 :
0.12毫升
价格2 :
290
size3 :
0.2毫升
价格3 :
435
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。