抗体

钙粘蛋白P单克隆抗体

MBS2542139

0.06毫升

220美元

单克隆

小鼠

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

钙粘蛋白P单克隆抗体

[钙粘蛋白P]

[CADH3; Cadherin 3; Cadherin 3 precursor; Cadherin 3 type 1; Cadherin-3; Cadp; Calcium dependent adhesion protein placental; CDH 3; CDH3; CDH3 protein; CDHP; HJMD; P cadherin (placental); P-cadherin; Placental cadherin]

[cadherin-3 isoform 2; Cadherin-3; cadherin-3; cadherin 3; Placental cadherin; P-cadherin]

[PCAD]

[CDH3]

[CDH3;CDH3;CDHP;HJMD;PCAD;CDHP;钙粘蛋白P]

单克隆

IgG1

小鼠

人类

784

蛋白质G纯化

PBS with 0.02% sodium azide, 50% glycerol, PH7.3

Store at -20 degree C. Avoid freeze / thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)

免疫印迹1:500-1:5000。 免疫组化1:50-1:500

免疫印迹(免疫印迹)

Immunogen: Fusion protein of CDH3

Note: Centrifuge before opening to ensure complete recovery of vial contents.

Cancer; Neuroscience; Signal transduction

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. P-cadherin (placental cadherin),also known as CDH3 (cadherin 3),is a classical member of the cadherin superfamily which also include E-,N-,R-,and B-cadherins. Aberrant expression of P-cadherin has been reported in many cancers,including breast,gastric,endometrial,ovarian,and prostate cancer.

953953841

NP_001304124.1

NM_001317195.1

P22223

Calculated MW: 829aa, 91kDa. Observed MW: 120kDa

Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233)

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

0.06毫升

220美元

0.12毫升

290

0.2毫升

435