抗体

活性的胱氨酸-天冬氨酸蛋白酶3单克隆抗体

MBS2548892

0.02毫升

110美元

单克隆

小鼠

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

抗体

活性的胱氨酸-天冬氨酸蛋白酶3单克隆抗体

[活性的胱氨酸-天冬氨酸蛋白酶3]

[CASP3,Caspase 3,apoptosis-related cysteine peptidase,apoptosis-related cysteine protease,. CPP-32,CPP32,CPP32B,Cysteine protease CPP32]

[caspase-3 isoform a preproprotein; Caspase-3; caspase-3; caspase 3; Apopain; Cysteine protease CPP32; CPP-32]

[CASP3;CASP3;CPP32;SCA-1;CPP32B;CPP32;CASP-3;CPP-32;SCA-1]

单克隆

IgG

小鼠

人类, 小鼠, 大鼠

277

蛋白质A纯化

存放在-20°C。 避免反复冷冻/解冻

免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡, 免疫荧光(IF)

WB: 1:500-1:1000。 IHC: 1:100-1:200。 IF: 1:100-1:200

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫荧光(IF)

Immunogen: Recombinant Protein. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.4. Observed MW: 17kDa

Cancer

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

14790119

NP_004337.2

NM_004346.3

P42574

AGE/RAGE Pathway (698754); Activation Of DNA Fragmentation Factor Pathway (105683); Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway (105672); Alpha6-Beta4 Integrin Signaling Pathway (198807); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099)

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. Protein type: Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease. Chromosomal Location of Human Ortholog: 4q35.1. Cellular Component: cytosol; membrane raft; nucleoplasm; nucleus; plasma membrane. Molecular Function: aspartic-type endopeptidase activity; caspase activator activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; death receptor binding; peptidase activity; phospholipase A2 activator activity; protease binding; protein binding; protein complex binding. Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptosis; apoptotic DNA fragmentation; B cell homeostasis; cell fate commitment; cellular response to DNA damage stimulus; erythrocyte differentiation; heart development; hippocampus development; intrinsic apoptotic signaling pathway in response to osmotic stress; keratinocyte differentiation; learning and/or memory; negative regulation of activated T cell proliferation; negative regulation of apoptosis; negative regulation of B cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; nerve growth factor receptor signaling pathway; neuron apoptosis; neuron differentiation; platelet formation; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of macroautophagy; response to amino acid; response to antibiotic; response to cobalt ion; response to drug; response to estradiol; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; response to tumor necrosis factor; response to UV; response to X-ray; sensory perception of sound; T cell homeostasis; wound healing

0.02毫升

110美元

0.06毫升

150

0.12毫升

225

0.2毫升

360