抗体

IL17A多克隆抗体

MBS2556071

0.06毫升

150美元

多克隆

兔

未共轭

小鼠, 大鼠

抗体

IL17A多克隆抗体

[IL17A]

[CTLA 8; CTLA-8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL 17A; IL-17; IL-17A; IL17; IL17; Il17a; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); Interleukin 17A; Interleukin-17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003]

[白细胞介素17A;白细胞介素17A;白细胞介素17A;白细胞介素17A;细胞毒性T淋巴细胞 抗原8;CTLA-8]

[IL17A]

[Il17a;Il17a;白细胞介素-17;Ctla8;IL-17;毒性T淋巴细胞相关抗原8;IL-17A;Ctla8;白细胞介素-17;IL-17;IL-17A;CTLA-8]

多克隆

IgG

兔

小鼠, 大鼠

158

亲和纯化

PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.

Store at -20 degree C. Avoid freeze/thaw cycles.

免疫组化(免疫组化)

IHC: 1:300-1:1000

免疫组化(免疫组化)

免疫组化(免疫组化)

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse IL-17A

Note: Centrifuge before opening to ensure complete recovery of vial contents.

Cancer; Immunology

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells, has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogenactivated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.

6754324

NP_034682.1

NM_010552.3

Q62386

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Rheumatoid Arthritis Pathway (200310); Rheumatoid Arthritis Pathway (200269)

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Ligand for IL17RA (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines ().

0.06毫升

150美元

0.12毫升

225

0.2毫升

360