产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
Canine Low Density Lipoprotein (LDL) ELISA Kit
目录 :
MBS2603730
规格 :
48-Strip-Wells
价格 :
275美元
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2603730 图像 1
产品信息
目录号 :
MBS2603730
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
Canine Low Density Lipoprotein (LDL) ELISA Kit
产品简称 :
[Low Density Lipoprotein]
其他名称 :
[low density lipoprotein, partial; Low-density lipoprotein receptor; low-density lipoprotein receptor; low density lipoprotein receptor]
产品基因名称 :
[LDL]
其他基因名称 :
[LDLR;LDLR;FH;FHC;LDLCQ2;低密度脂蛋白受体]
UniProt数据库进入名 :
LDLR_HUMAN
反应物种 :
序列长度 :
76
特异性 :
No cross-reaction with other factors.
储存稳定性 :
Store all reagents at 2-8 degree C.
image1头 :
Typical Testing Data/Standard Curve (for reference only)
其它信息1 :
Samples: Canine Serum, Plasma Or Cell Culture Supernatant And Organizations In The Natural And Recombinant Lam Concentration. Assay Type: Sandwich. Detection Range: 200 ng/ml-3.12 ng/ml. Sensitivity: 0.6 ng/ml.
其他信息2 :
Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%
产品描述 :
Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Canine LAM monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
NCBI GI登录号 :
306411097
NCBI登录号 :
ADM85894.1
NCBI分子量 :
82,255 Da
NCBI信号通路 :
Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Chylomicron-mediated Lipid Transport Pathway (1270006); DNA Damage Response (only ATM Dependent) Pathway (198827); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907)
NCBI总结 :
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
UniProt数据库总结 :
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc.; Cell surface. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; coated pit; early endosome; endosome membrane; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; late endosome; lysosome; membrane; plasma membrane; receptor complex. Molecular Function: calcium ion binding; clathrin heavy chain binding; glycoprotein binding; identical protein binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protease binding; protein binding; receptor activity; very-low-density lipoprotein receptor activity; viral receptor activity. Biological Process: cholesterol absorption; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endocytosis; entry of virus into host cell; fat-soluble vitamin metabolic process; lipid metabolic process; lipoprotein catabolic process; lipoprotein metabolic process; phospholipid transport; phototransduction, visible light; receptor-mediated endocytosis; retinoid metabolic process; vitamin metabolic process. Disease: Hypercholesterolemia, Familial
尺寸1 :
48-Strip-Wells
价格1 :
275美元
尺寸2 :
96-Strip-Wells
价格2 :
435
size3 :
5x96-Strip-Wells
价格3 :
1755
size4 :
10x96-Strip-Wells
price4 :
3150
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。