产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
小鼠白细胞介素8(IL-8)酶联免疫吸附试剂盒
目录 :
MBS261967
规格 :
48-Strip-Wells
价格 :
290美元
更多信息或购买 :
文章摘录数: 1
参考文献
Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, et al. Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Aging (Albany NY). 2019;11:11659-11672 pubmed 出版商
产品信息
目录号 :
MBS261967
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
小鼠白细胞介素8(IL-8)酶联免疫吸附试剂盒
产品简称 :
白细胞介素8(IL-8)
其他名称 :
interleukin-8; Interleukin-8; interleukin-8; emoctakin; interleukin 8; T-cell chemotactic factor; neutrophil-activating peptide 1; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; tumor necrosis factor-induced gene 1; alveolar macrophage chemotactic factor I; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lymphocyte derived neutrophil activating peptide; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide; chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-aAlternative name(s):GCP/IL-8 protein IV; IL8/NAP1 form I
产品基因名称 :
IL-8
其他基因名称 :
CXCL8;CXCL8;白细胞介素-8;NAF;GCP1;LECT;LUCT;NAP1;GCP-1;LYNAP;MDNCF;MONAP;NAP-1;白细胞介素-8;IL-8;GCP-1;MDNCF;MONAP;NAP-1;LYNAP;NAF
UniProt数据库进入名 :
IL8_HUMAN
反应物种 :
小鼠
序列长度 :
99
特异性 :
No cross-reaction with other factors.
储存稳定性 :
Store all reagents at 2-8 degree C.
其它信息1 :
Samples: Mouse serum, plasma or cell culture supernatant and organizations in the natural and recombinant IL-8 concentration. Assay Type: Quantitative Sandwich. Sensitivity: Up to 5 pg/ml.
其他信息2 :
Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%
产品描述 :
Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Mouse IL-8 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
NCBI GI登录号 :
10834978
NCBI登录号 :
NP_000575.1
NCBI基因登录号 :
NM_000584.3
NCBI分子量 :
11,338 Da
NCBI信号通路 :
ATF-2 Transcription Factor Network Pathway (138006); Activation Of Genes By ATF4 Pathway (530772); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chemokine Receptors Bind Chemokines Pathway (106359)
NCBI总结 :
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Cytokine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q13-q21. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity; interleukin-8 receptor binding. Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; unfolded protein response; negative regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; signal transduction; chemotaxis; regulation of retroviral genome replication; induction of positive chemotaxis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; receptor internalization; response to molecule of bacterial origin; immune response; angiogenesis; cell motility; cell cycle arrest; inflammatory response; embryonic gut development
尺寸1 :
48-Strip-Wells
价格1 :
290美元
尺寸2 :
96-Strip-Wells
价格2 :
450
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。