产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
Human Bisphenol A (BPA) ELISA Kit
目录 :
MBS269957
规格 :
48-Strip-Wells
价格 :
275美元
更多信息或购买 :
产品信息
目录号 :
MBS269957
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
Human Bisphenol A (BPA) ELISA Kit
产品简称 :
Bisphenol A (BPA)
其他名称 :
bisphenol A receptor ERRgamma2; Estrogen-related receptor gamma; estrogen-related receptor gamma; ERR gamma-2; estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3; estrogen-related receptor gamma; ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3
产品基因名称 :
BPA
其他基因名称 :
ESRRG;ESRRG;ERR3;NR3B3;ERRgamma;ERR3;ERRG2;KIAA0832;NR3B3
UniProt数据库进入名 :
ERR3_HUMAN
反应物种 :
人类
序列长度 :
435
特异性 :
No cross-reaction with other factors.
储存稳定性 :
Store all reagents at 2-8 degree C.
其它信息1 :
Samples: Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant BPA concentration. Assay Type: Quantitative Sandwich. Sensitivity: Up to 0.6 ng/ml.
其他信息2 :
Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%
产品描述 :
Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human BPA monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
NCBI GI登录号 :
226000901
NCBI登录号 :
BAH36764.1
NCBI分子量 :
52,462 Da
NCBI信号通路 :
Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979)
NCBI总结 :
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
UniProt数据库总结 :
ERR3: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor; Nuclear receptor. Chromosomal Location of Human Ortholog: 1q41. Cellular Component: nucleoplasm. Molecular Function: protein binding; AF-2 domain binding; zinc ion binding; steroid hormone receptor activity; retinoic acid receptor activity; steroid binding. Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
尺寸1 :
48-Strip-Wells
价格1 :
275美元
尺寸2 :
96-Strip-Wells
价格2 :
420
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。