ELISA/assay

Human Neurofilament light polypeptide ELISA Kit

MBS2886650

48-Strip-Wells

355美元

酶联免疫吸附试剂盒

Human Neurofilament light polypeptide ELISA Kit

[Neurofilament light polypeptide]

[Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein; NEFL; NF68; NFL]

[neurofilament light polypeptide; Neurofilament light polypeptide; neurofilament light polypeptide; neurofilament, light polypeptide; 68 kDa neurofilament protein; Neurofilament triplet L protein]

[NEFL]

[NEFL;NEFL;NFL;NF-L;NF68;CMT1F;CMT2E;PPP1R110;NF68;NFL;NF-L]

NFL_HUMAN

人类

543

For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, Plasma, Tissue Homogenates, Cell Culture Supernates Or Other Biological Fluids.

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

105990539

NP_006149.2

NM_006158.4

P07196

61,517 Da

ARMS-mediated Activation Pathway (1269471); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Axon Guidance Pathway (1270303); CREB Phosphorylation Through The Activation Of CaMKII Pathway (1268805); CREB Phosphorylation Through The Activation Of Ras Pathway (1268801); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 8p21. Cellular Component: axon; cytoplasm; cytosol; growth cone; myelin sheath; neurofilament; TSC1-TSC2 complex. Molecular Function: identical protein binding; phospholipase binding; protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton. Biological Process: activation of MAPKK activity; anterograde axon cargo transport; axon guidance; axon regeneration in the peripheral nervous system; axon transport of mitochondrion; cerebral cortex development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; hippocampus development; innate immune response; insulin receptor signaling pathway; intermediate filament organization; intermediate filament polymerization and/or depolymerization; MAPKKK cascade; microtubule cytoskeleton organization and biogenesis; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; neurofilament bundle assembly; neuromuscular process controlling balance; positive regulation of axonogenesis; protein polymerization; Ras protein signal transduction; regulation of axon diameter; response to corticosterone stimulus; response to toxin; retrograde axon cargo transport; small GTPase mediated signal transduction; spinal cord development; synaptic transmission; vascular endothelial growth factor receptor signaling pathway. Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f

48-Strip-Wells

355美元

96-Strip-Wells

475

5x96-Strip-Wells

2030

10x96-Strip-Wells

3700