产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗人类COX-2单克隆抗体(克隆SP21)
目录 :
MBS302577
规格 :
0.1毫升
价格 :
265美元
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
SP21
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录号 :
MBS302577
产品类型 :
抗体
产品全称 :
兔抗人类COX-2单克隆抗体(克隆SP21)
产品简称 :
COX-2
其他名称 :
prostaglandin G/H synthase 2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase 2; PGH synthase 2; PHS II; cyclooxygenase 2b; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
产品基因名称 :
COX-2
其他基因名称 :
PTGS2; PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; COX2; COX-2; PGH synthase 2; PGHS-2
UniProt数据库进入名 :
PGH2_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG
克隆 :
SP21
宿主 :
反应物种 :
Human. Predicted Reactivity: Bovine, Dog, Frog, Mouse, Rat
序列长度 :
604
形式 :
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
储存稳定性 :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
检测过的应用 :
免疫组化(免疫组化)石蜡
应用笔记 :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Colon Adenoarcinoma, Lung, Breast Carcinoma
其他信息2 :
Immunogen: Synthetic peptide corresponding to C-terminus of rat COX-2. Control Tissue: Breast Carcinoma, Colon, Lung. Cellular Localization: Cytoplasm, Membrane. Entrez Gene Code: 5743. Pathway: Oncogenesis
产品描述 :
COX2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
NCBI GI登录号 :
4506265
NCBI登录号 :
NP_000954.1
NCBI基因登录号 :
NM_000963.3
NCBI分子量 :
70 kDa
NCBI信号通路 :
Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553!!Arachidonic Acid Metabolism Pathway 366!!C-MYB Transcription Factor Network Pathway 138073!!C20 Prostanoid Biosynthesis Pathway 545299!!C20 Prostanoid Biosynthesis Pathway 908107!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Calcium Signaling In The CD4+ TCR Pathway 137941!!Chemical Carcinogenesis Pathway 673221!!Chemical Carcinogenesis Pathway 673237
NCBI总结 :
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
规格 :
0.1毫升
价格 :
265美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。