MyBioSource

蛋白

重组人类ALK/p80蛋白

MBS306001

0.01毫克

420美元

MBS306001

重组蛋白

重组人类ALK/p80蛋白

ALK/p80

ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246

ALK/p80

ALK;ALK;CD246;NBLST3

ALK_HUMAN

1620

Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

Source: Recombinant ALK/p80 protein encoding 426-528aa expressed in E Coli.

Domain: aa 426-528

29029632

NP_004295.2

NM_004304.4

176,442 Da

Non-small Cell Lung Cancer Pathway 83119!!Non-small Cell Lung Cancer Pathway 531

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

0.01毫克

420美元