抗体

MAb to TNF Alpha

MBS311184

1毫克

490美元

单克隆

小鼠

未共轭

2C8

酶联免疫吸附测定, 酶免疫法

抗体

MAb to TNF Alpha

肿瘤坏死因子α(肿瘤坏死因子-a)

单克隆抗体人类肿瘤坏死因子α(肿瘤坏死因子甲)

tumor necrosis factor; Tumor necrosis factor; tumor necrosis factor; TNF-a; cachectin; APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2

肿瘤坏死因子;肿瘤坏死因子;DIF;TNFA;TNFSF2;肿瘤坏死因子甲;TNFA;TNFSF2

TNFA_HUMAN

单克隆

IgG1

2C8

Mouse. Hybridization of X63.Ag8.653 myeloma cells with spleen cells from BALB/c mice.

233

Tumor Necrosis Factor alpha (TNF-a). Effective in inhibition of the biological activity of recombinant and natural TNF-alpha.

>90% pure (SDS-PAGE). Protein A chromatography

纯化, 液体

6.3毫克/毫升(OD280nm, E^0.1% = 1.4)

Store at 2 to 8 degree C.

EIA/酶联免疫吸附测定, 免疫组化-福尔马林, 免疫测定抗体配对

Inhibition of biological activity of TNF-alpha in different biological fluids. Detection of TNF-alpha in two-site immunoassay. Immunohistochemistry using formalin-fixed frozen tissues. Not tested with paraffin-embedded sections.Each laboratory sh

Immunogen: Human recombinant tumor necrosis factor of alpha type. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Cytokines and Growth Factors

25952111

NP_000585.2

NM_000594.2

P01375

25,644 Da

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198832!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Amoebiasis Pathway 167324

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq]

Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Subunit structure: Homotrimer. Subcellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. Ref.18 Ref.19O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. Ref.15. Polymorphism: Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [. MIM:610424]. Involvement in disease: Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [. MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Sequence similarities: Belongs to the tumor necrosis factor family. Sequence caution: The sequence AAF71992.1 differs from that shown. Reason: Frameshift at positions 91 and 157. The sequence CAA75070.1 differs from that shown. Reason: Erroneous gene model prediction.

1毫克

490美元