产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MAb to CD36
目录 :
MBS311750
规格 :
0.2毫克
价格 :
325美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
289-10930
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
MBS311750
产品类型 :
抗体
产品全称 :
MAb to CD36
产品简称 :
CD36
产品名称同义词 :
单克隆抗体人类CD36
其他名称 :
CD36; Platelet glycoprotein 4; platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor
其他基因名称 :
CD36;CD36;脂肪;GP4;GP3B;GPIV;CHDS7;PASIV;SCARB3;GP3B;GP4
UniProt数据库进入名 :
CD36_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgM
克隆 :
289-10930(SM?)
宿主 :
Host: Mouse. Source: Tissue Culture
反应物种 :
人类
序列长度 :
472
特异性 :
CD36。 人类CD36
纯度 :
>90% pure (SDS-PAGE). S-300 Sepharose size exclusion chromatography.
形式 :
纯化, 液体
浓度 :
1.0毫克/毫升(OD280nm, E^0.1% = 1.2)
储存稳定性 :
Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
其它信息1 :
Immunogen: Human tonsil cells and PBM. Affinity Constant: Not determined
其他信息2 :
Buffer: 10mM Phosphate, pH 7.4 containing 150mM Sodium chloride. Preservative: 0.1% Sodium Azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
产品种类 :
Monoclonal Antibodies to Human CDs
产品引用 :
Hogg, N.H. et al (1984) Immunology 53:753. Linch, D.C et al (1984) Blood 63:566
NCBI GI登录号 :
525233
NCBI登录号 :
CAA83662.1
UniProt数据库登录号 :
P16671
NCBI分子量 :
53,053 Da
NCBI信号通路 :
Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Collagen Adhesion Via Gp IV Pathway 106032!!Diabetes Pathways 105902!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Fat Digestion And Absorption Pathway 194385!!Fat Digestion And Absorption Pathway 194324!!Formation Of Platelet Plug Pathway 106029!!Hematopoietic Cell Lineage Pathway 83078
NCBI总结 :
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
UniProt数据库总结 :
Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22. Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12. Subcellular location: Membrane; Multi-pass membrane protein. Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16. Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection. Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[. MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [. MIM:610938]. Ref.23. Sequence similarities: Belongs to the CD36 family. Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.
规格 :
0.2毫克
价格 :
325美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。