产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MAb to Thrombin Receptor
目录 :
MBS311836
规格 :
0.2毫克
价格 :
610美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
B825M
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS311836
产品类型 :
抗体
产品全称 :
MAb to Thrombin Receptor
产品简称 :
凝血酶受体
产品名称同义词 :
单克隆抗体凝血酶受体
其他名称 :
凝血酶受体;凝血酶受体蛋白;蛋白酶激活受体;凝血酶受体;OTTHUMP00000161974;蛋白酶激活受体1;凝血因子II受体;凝血因子II(凝血酶)受体
其他基因名称 :
F2R;凝血酶受体;TR;HTR;CF2R;PAR1;PAR-1
UniProt数据库进入名 :
Q16292_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
B825M
宿主 :
Host: Mouse. Hybridization of Sp2 myeloma cells with spleen cells from BALB/c mice. Source: Ascites
特异性 :
Thrombin Receptor. Recognizes an epitope on the receptor, distant from the N-terminal thrombin cleavage site (WEDEE). It reacts with both intact and cleaved receptors.
纯度 :
蛋白质A色谱
形式 :
Purified, Lyophilized. Reconstitute with 1ml distilled water.
浓度 :
0.2mg/ml (prior to lyophilization)
储存稳定性 :
Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage (up to one month) at 2 to 8 degree C.
检测过的应用 :
流式细胞仪, 免疫沉淀, 免疫印迹
其它信息1 :
Immunogen: N-terminal peptide of thrombin receptor residues 51-64 (KYEPFWEDEEKNES). Affinity Constant: Not determined
其他信息2 :
Buffer: Lyophilized from PBS containing 1mg/ml BSA. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
产品种类 :
Monoclonal Antibodies to Platelets and Hemostasis Antigens
产品引用 :
Vu, T.-K.H., et al., (1991), "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation", Cell, 64, 1057-1068. Brass, L.F., et al., (1992), "Structure and function of the hum
NCBI GI登录号 :
4261929
UniProt数据库登录号 :
Q16292
NCBI分子量 :
9,774 Da
NCBI信号通路 :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Formation Of Platelet Plug Pathway (106029); G Alpha (q) Signalling Events Pathway (106043)
NCBI总结 :
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq]
UniProt数据库总结 :
PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development. Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Cell development/differentiation. Chromosomal Location of Human Ortholog: 5q13. Cellular Component: Golgi apparatus; postsynaptic membrane; integral to plasma membrane; early endosome; extracellular region; plasma membrane; caveola; neuromuscular junction. Molecular Function: G-protein coupled receptor activity; protein binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; thrombin receptor activity; receptor binding. Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of blood coagulation; activation of MAPKK activity; negative regulation of glomerular filtration; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; positive regulation of JAK-STAT cascade; positive regulation of caspase activity; response to lipopolysaccharide; negative regulation of cell proliferation; connective tissue replacement during inflammatory response; elevation of cytosolic calcium ion concentration; platelet dense granule organization and biogenesis; positive regulation of MAPKKK cascade; regulation of interleukin-1 beta production; positive regulation of cell proliferation; protein kinase C activation; response to wounding; negative regulation of neuron apoptosis; positive regulation of smooth muscle contraction; establishment of synaptic specificity at neuromuscular junction; inflammatory response; STAT protein nuclear translocation; caspase activation; platelet activation; anatomical structure morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; tyrosine phosphorylation of STAT protein; homeostasis of number of cells within a tissue; release of sequestered calcium ion into cytosol; regulation of blood coagulation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; positive regulation of calcium ion transport; positive regulation of cell migration
尺寸1 :
0.2毫克
价格1 :
610美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。