抗体

MAb to Erythropoietin

MBS311940

0.5毫克

650美元

单克隆

小鼠

未共轭

85

酶联免疫吸附测定, 酶免疫法

抗体

MAb to Erythropoietin

促红细胞生成素(EPO)

单克隆抗体人类促红细胞生成素(EPO)

erythropoietin; Erythropoietin; erythropoietin; epoetin; OTTHUMP00000201234; erythropoietin

EPO;EP;MVCD2;MGC138142

EPO_HUMAN

单克隆

IgG1

85

Host: Mouse. Hybridization of Sp2/0-Ag14 myeloma cells w/spleen cells from Balb/c mice. Source: Ascites

人类

193

Erythropoietin (EPO). Human EPO. Does not cross-react with other human cytokines tested such as IL-8, IL-16, IL-7, MCP-1, TNF-beta, GM-CSF, M-CSF, IL-1beta, bFGF and human serum albumin or bovine serum albumin.

蛋白质G色谱

Purified, Lyophilized. Reconstitute in double distilled water to a concentration of 1mg/ml.

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

EIA/酶联免疫吸附测定

Immunogen: Purified CHO cell-expressed recombinant human EPO. Affinity Constant: Not determined

Buffer: Lyophilized from 0.01M PBS, pH 7.2. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Monoclonal Antibodies to Cytokines and Growth Factors

312304

CAA26095.1

P01588

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq]

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular space; cell surface; extracellular region. Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity. Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of Ras protein signal transduction; response to axon injury; positive regulation of neuron differentiation; response to electrical stimulus; positive regulation of DNA replication; embryo implantation; aging. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2

0.5毫克

650美元