抗体

兔抗小鼠ApoE基因B48/100

MBS315481

1毫升

285美元

多克隆

兔

未共轭

人类, 小鼠

抗体

兔抗小鼠ApoE基因B48/100

载脂蛋白b-48/100(载脂蛋白B-48/100)

兔抗体小鼠载脂蛋白B48/100(ApoE基因B48/100)

载脂蛋白b-100;载脂蛋白b-100;载脂蛋白b-100;载脂蛋白B 48;载脂蛋白B 100;载脂蛋白B-100;突变体载脂蛋白B 100;OTTHUMP00000115994;载脂蛋白B48;载脂蛋白b(包括老化(x)抗原)

载脂蛋白B;载脂蛋白B;FLDB;LDLCQ4

APOB_HUMAN

多克隆

新西兰兔

小鼠

4563

Apolipoprotein B-48/100 (Apo B-48/100). Recognizes mouse as well as human Apo B48 and B100 as these proteins are highly conserved.

Not applicable. Heat inactivated. Product is 0.22um filtered.

Neat, Liquid

Not determined. Titer: 1:30 (RID)

Upon receipt, aliquot and store at -70 degree C. Avoid multiple freeze/thaw cycles.

RID, 免疫印迹

Radial immunodiffusion assay and immunoblotting. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Immunogen: Mouse very low density lipoprotein (LDL)

Buffer: Not applicable. Preservative: 0.05% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Polyclonal Antibodies to Lipoproteins

Brown, R.J., et al., (2004), "Severe Hypoalphalipoproteinemia in Mice Expressing Human Hepatic Lipase Deficient in Binding to Heparan Sulfate Proteoglycan", The Journal of Biological Chemistry, 279(41): 42403-42409. Fu, T., et al

105990532

NP_000375.2

NM_000384.2

P04114

515,605 Da

Cell Surface Interactions At The Vascular Wall Pathway (106062); Chylomicron-mediated Lipid Transport Pathway (106157); FOXA1 Transcription Factor Network Pathway (137979); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Formation Of Platelet Plug Pathway (106029); Hemostasis Pathway (106028); LDL-mediated Lipid Transport Pathway (106159); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156)

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA- UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq]

Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Subcellular location: Secreted. Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Ref.34. Post-translational modification: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. Ref.31. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) [. MIM:107730]. A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Ref.46Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [. MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Ref.40 Ref.42 Ref.44Note=Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. Sequence similarities: Contains 1 vitellogenin domain. RNA editing: Edited at position 2180.The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL. Sequence caution: The sequence AAA51752.1 differs from that shown. Reason: Frameshift at positions 942, 951, 1139, 1165, 1164, 1371 and 1385.

1毫升

285美元