产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗PAI-1
目录 :
MBS315810
规格 :
0.2毫克
价格 :
420美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS315810
产品类型 :
抗体
产品全称 :
兔抗PAI-1
产品简称 :
纤溶酶原激活物抑制因子1
产品名称同义词 :
兔抗体人类纤溶酶原激活物抑制因子1(PAI-1)
其他名称 :
plasminogen activator inhibitor 1 isoform 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1
其他基因名称 :
SERPINE1;SERPINE1;PAI;PAI1;PAI-1;PLANH1;PAI1;PLANH1
UniProt数据库进入名 :
PAI1_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类
序列长度 :
402
特异性 :
Plasminogen Activator Inhibitor 1. Recognizes Human PAI-1 both alone and in complex under reducing and native conditions.
纯度 :
蛋白质A色谱
形式 :
纯化, 液体
浓度 :
7.0毫克/毫升(OD280nm, E^0.1% = 1.36)
储存稳定性 :
Store at -70 degree C. Avoid multiple freeze/thaw cycles.
检测过的应用 :
EIA/酶联免疫吸附测定, 免疫组化, 免疫印迹
其它信息1 :
Immunogen: Recombinant human PAI-1
其他信息2 :
Buffer: 0.05M Sodium phosphate, 0.1M Sodium chloride, 1mM EDTA, pH 6.6. Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
产品种类 :
Polyclonal Antibodies to Platelets and Hemostasis Antigens
NCBI GI登录号 :
10835159
NCBI登录号 :
NP_000593.1
NCBI基因登录号 :
NM_000602.3
UniProt数据库登录号 :
P05121
NCBI分子量 :
45,060 Da
NCBI信号通路 :
Adipogenesis Pathway (198832); Blood Clotting Cascade Pathway (198840); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Circadian Clock Pathway (187173); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Direct P53 Effectors Pathway (137939); Dissolution Of Fibrin Clot Pathway (106061)
NCBI总结 :
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt数据库总结 :
Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Subunit structure: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Ref.14 Ref.16. Subcellular location: Secreted. Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Post-translational modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. Involvement in disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [. MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Ref.15Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Sequence similarities: Belongs to the serpin family.
尺寸1 :
0.2毫克
价格1 :
420美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。