产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MYBPC3抗体-C末端地区
目录 :
MBS3205809
规格 :
0.1毫升
价格 :
335美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS3205809 图像 1
Host: Rabbit. Target Name: MYBPC3. Sample Type: MCF7 Whole cell lysates. Antibody Dilution: 1.0ug/ml
产品信息
目录号 :
MBS3205809
产品类型 :
抗体
产品全称 :
MYBPC3抗体-C末端地区
产品简称 :
[MYBPC3]
其他名称 :
[myosin-binding protein C, cardiac-type; Myosin-binding protein C, cardiac-type; myosin-binding protein C, cardiac-type; myosin binding protein C, cardiac; C-protein, cardiac muscle isoform]
产品基因名称 :
[MYBPC3]
产品基因名称同义词 :
[FHC;CMH4;CMD1MM;LVNC10;MYBP-C]
其他基因名称 :
[MYBPC3; MYBPC3; FHC; CMH4; CMD1MM; LVNC10; MYBP-C; Cardiac MyBP-C]
UniProt数据库进入名 :
MYPC3_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
Tested: Human; Predicted: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
序列长度 :
365
序列 :
KGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQP
AFTGSYRCEVS
Synthetic peptide located within the following region:
纯度 :
亲和纯化
形式 :
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
浓度 :
Batch dependent within range: 100 ul at 0.5-1 mg/ml
储存稳定性 :
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹)
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Protein Size (#AA): 365 amino acids. Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%. Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human MYBPC3
其他信息2 :
Replacement Item: This antibody may replace item sc-112857 from Santa Cruz Biotechnology
产品种类 :
Polyclonal; Various;
产品描述 :
This is a rabbit polyclonal antibody against MYBPC3. It was validated on Western Blot. Target Description: MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
NCBI GI登录号 :
148596957
NCBI登录号 :
NP_000247.2
NCBI基因登录号 :
NM_000256.3
UniProt数据库登录号 :
Q14896
NCBI分子量 :
40kDa
NCBI信号通路 :
Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)
NCBI总结 :
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. Protein type: Myosin-binding. Chromosomal Location of Human Ortholog: 11p11.2. Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band. Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding. Biological Process: heart morphogenesis; regulation of heart rate; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; cell adhesion; myosin filament assembly; muscle filament sliding; cardiac muscle contraction. Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4
尺寸1 :
0.1毫升
价格1 :
335美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。